Taylor A, Ziffer J A, Steves A, Eshima D, Delaney V B, Welchel J D
Department of Radiology, Emory University School of Medicine, Atlanta, GA.
Radiology. 1989 Mar;170(3 Pt 1):721-5. doi: 10.1148/radiology.170.3.2521734.
Previous studies in animals and humans have shown that technetium-99m mercaptoacetyltriglycine (MAG3) purified by high-performance liquid chromatography is a renal tubular agent with characteristics similar to those of iodine-131 orthoiodohippurate (OIH). A kit formulation for Tc-99m MAG3 has been developed and compared with I-131 OIH in 17 patients with suspected renal dysfunction and three potential kidney donors. There were no adverse reactions. Tc-99m MAG3 images were of good quality and consistently better than I-131 OIH images. There was no significant difference in the relative renal uptake of Tc-99m MAG3 and I-131 OIH. The 30-minute urinary excretion of Tc-99m MAG3 was 36.4%, versus 40.4% for I-131 OIH. The average plasma clearance of Tc-99m MAG3 (138 mL/min +/- 117) was less than that of I-131 OIH (272 mL/min +/- 205) (P less than .001); however, there was good correlation between the Tc-99m MAG3 and I-131 OIH clearances (r = .87). The volume of distribution of Tc-99m MAG3 (5.96 L +/- 1.94) was less than that of I-131 OIH (9.41 L +/- 3.73) (P less than .001). These characteristics and the advantages of a simple kit formulation should lead to widespread clinical use.
先前在动物和人体中的研究表明，通过高效液相色谱法纯化的锝-99m 巯基乙酰三甘氨酸（MAG3）是一种肾小管显像剂，其特性与碘-131 邻碘马尿酸（OIH）相似。现已开发出一种用于锝-99m MAG3 的试剂盒配方，并在 17 例疑似肾功能不全患者和 3 名潜在肾脏供体中与碘-131 OIH 进行了比较。未出现不良反应。锝-99m MAG3 图像质量良好，且始终优于碘-131 OIH 图像。锝-99m MAG3 和碘-131 OIH 的相对肾脏摄取量无显著差异。锝-99m MAG3 的 30 分钟尿液排泄率为 36.4%，而碘-131 OIH 为 40.4%。锝-99m MAG3 的平均血浆清除率（138 mL/分钟±117）低于碘-131 OIH（272 mL/分钟±205）（P＜0.001）；然而，锝-99m MAG3 和碘-131 OIH 的清除率之间存在良好的相关性（r = 0.87）。锝-99m MAG3 的分布容积（5.96 L±1.94）小于碘-131 OIH（9.41 L±3.73）（P＜0.001）。这些特性以及简单试剂盒配方的优势应会促使其在临床上广泛应用。
