Kabasakal L, Turoğlu H T, Onsel C, Ozker K, Uslu I, Atay S, Cansiz T, Sönmezoğlu K, Altiok E, Isitman A T
Department of Nuclear Medicine, Cerrahpaşa Medical Faculty of Istanbul University, Turkey.
J Nucl Med. 1995 Feb;36(2):224-8.
Technetium-99m-ethylenedicysteine has recently been developed for renal function studies. The pharmacokinetics of 99mTc-EC were studied by constant infusion technique and compared with 99mTc-MAG3 and 131I-OIH in 11 patients with various renal disorders.
After giving a 7.4 MBq 131I-OIH and 90-110 MBq 99mTc-EC or 99mTc-MAG3 bolus, a constant infusion (1MBq/ml 99mTc-agent and 0.07 MBq/m 131I-OIH was started. Sixteen blood and five urine samples were obtained over three hr.
The renal clearance of 99mTc-EC was higher than that of 99mTc-MAG3. The 99mTc-EC/OIH and 99mTc-MAG3/OIH ratios were 0.75 +/- 0.05 and 0.55 +/- 0.10 (p = 0.00087), respectively. The distribution volume of 99mTc-EC was also higher than that of 99mTc-MAG3 (15722 +/- 4644 and 9509 +/- 2788 ml/1.73m2, respectively; p = 0.072). The 99mTc-EC/OIH and 99mTc-MAG3/OIH distribution volume ratios were 1.03 +/- 0.14 and 0.55 +/- 0.10, respectively (p = 0.0003). The 60-min excretion values of 99mTc-EC and 99mTc-MAG3 were compared to that of OIH. The 99mTc-EC/OIH and 99mTc-MAG3/OIH excretion ratios were 0.96 +/- 0.06 and 1.07 +/- 0.10, respectively (p = 0.162). The protein binding of 99mTc-EC and OIH were found to be 34% +/- 4 and 66% +/- 5, respectively (p < 0.0001). The red cell binding of 99mTc-EC was negligible (3% +/- 1.2) in comparison to OIH (27% +/- 3; p < 0.0001).
This limited study demonstrates the pharmacokinetic and renal clearance properties of 99mTc-EC. This agent has good potential for renal function evaluation.
锝-99m-乙二半胱氨酸最近已被开发用于肾功能研究。采用持续输注技术研究了99mTc-EC的药代动力学，并与11例各种肾脏疾病患者的99mTc-MAG3和131I-OIH进行了比较。
静脉推注7.4MBq 131I-OIH和90-110MBq 99mTc-EC或99mTc-MAG3后，开始持续输注（1MBq/ml 99mTc标记剂和0.07MBq/ml 131I-OIH）。在3小时内采集16份血液和5份尿液样本。
99mTc-EC的肾脏清除率高于99mTc-MAG3。99mTc-EC/OIH和99mTc-MAG3/OIH的比率分别为0.75±0.05和0.55±0.10（p = 0.00087）。99mTc-EC的分布容积也高于99mTc-MAG3（分别为15722±4644和9509±2788ml/1.73m2；p = 0.072）。99mTc-EC/OIH和99mTc-MAG3/OIH的分布容积比率分别为1.03±0.14和0.55±0.10（p = 0.0003）。比较了99mTc-EC和99mTc-MAG3在60分钟时的排泄值与OIH的排泄值。99mTc-EC/OIH和99mTc-MAG3/OIH的排泄比率分别为0.96±0.06和1.07±0.10（p = 0.162）。发现99mTc-EC和OIH的蛋白结合率分别为34%±4和66%±5（p < 0.0001）。与OIH（27%±3；p < 0.0001）相比，99mTc-EC与红细胞的结合可以忽略不计（3%±1.2）。
这项有限的研究证明了99mTc-EC的药代动力学和肾脏清除特性。该药物在肾功能评估方面具有良好的潜力。
