Ozker K, Onsel C, Kabasakal L, Sayman H B, Uslu I, Bozluolçay S, Cansiz T, Kapicioğlu T, Urgancioğlu I
Department of Nuclear Medicine, Cerrahpaşa Medical Faculty, Istanbul, Turkey.
J Nucl Med. 1994 May;35(5):840-5.
Technetium-99m-labeled N,N-ethylenedicysteine (99mTc-EC) is a new renal imaging agent introduced as an alternative for 99mTc-labeled mercaptoacetyltriglycine (99mTc-MAG3), with similar renal excretion characteristics. To evaluate the diagnostic characteristics of this agent, a gamma camera study was performed.
Sixteen patients with obstructive renal disease and six normal controls were injected with 90 to 110 MBq of 99mTc-EC and 7.4 MBq 131I-labeled orthoiodohippurate (OIH). Serial images were obtained during 20 min for 99mTc-EC and 30 min for OIH. The study was repeated using 90 to 110 MBq 99mTc-MAG3 during the same week.
Renograms, functional ratios and urinary excretion patterns of all three agents were similar. The mean time to peak activity values for OIH, 99mTc-EC and 99mTc-MAG3 were 4.25 +/- 0.37 min, 4.39 +/- 0.32 min and 4.00 +/- 0.24 min, respectively. The time from peak to 50% activity values for OIH, 99mTc-EC and 99mTc-MAG3 were 5.48 +/- 0.80 min, 6.93 +/- 0.69 min and 7.33 +/- 0.85 min, respectively.
It is concluded that 99mTc-EC has excellent imaging characteristics and similar excretion properties to OIH. The advantages of 99mTc-EC over 99mTc-MAG3 are lower hepatobiliary uptake and simplicity of preparation.
锝-99m标记的N,N-乙二巯基丁二酸（99mTc-EC）是一种新的肾脏显像剂，作为锝-99m标记的巯基乙酰三甘氨酸（99mTc-MAG3）的替代物被引入，具有相似的肾脏排泄特性。为评估该显像剂的诊断特性，进行了γ相机研究。
对16例梗阻性肾病患者和6例正常对照者注射90至110MBq的99mTc-EC和7.4MBq的131I标记的邻碘马尿酸（OIH）。分别在20分钟内获取99mTc-EC的系列图像，在30分钟内获取OIH的系列图像。在同一周内使用90至110MBq的99mTc-MAG3重复该研究。
三种显像剂的肾图、功能比值和尿排泄模式相似。OIH、99mTc-EC和99mTc-MAG3达到峰值活性值的平均时间分别为4.25±0.37分钟、4.39±0.32分钟和4.00±0.24分钟。OIH、99mTc-EC和99mTc-MAG3从峰值到活性值降至50%的时间分别为5.48±0.80分钟、6.93±0.69分钟和7.33±0.85分钟。
得出结论，99mTc-EC具有优异的显像特性，且排泄特性与OIH相似。99mTc-EC相对于99mTc-MAG3的优势在于较低的肝胆摄取率和制备简单。
