Minar E, Ehringer H, Ahmadi R, Dudczak R, Leitha T, Koppensteiner R, Jung M, Stümpflen A
Department of Angiology, Medical University Clinic Vienna, Austria.
Radiology. 1989 Mar;170(3 Pt 1):767-72. doi: 10.1148/radiology.170.3.2521736.
The amount and time course of platelet accumulation at angioplasty sites and influence of these platelets on restenosis after percutaneous transluminal angioplasty (PTA) in peripheral arteries were determined in 92 patients, who received either a high or low dose of aspirin. Platelet deposition was quantitated by means of dual-radiotracer scintigraphy and calculation of a platelet accumulation index (PAI). The PAI was higher (P less than .05) 4-6 hours after PTA compared with that on subsequent days. There was a trend toward greater platelet accumulation in vessels with extensive dissection. Platelet accumulation at the PTA site occurred with both doses of aspirin, with no differences between the two dosage groups. Twenty-one of 67 patients who underwent PTA in the femoropopliteal segment developed restenosis during a median follow-up of 14 months. The median PAI at 4-6 and 22-24 hours after PTA was significantly less in these 21 patients than in the 46 without restenosis. The data suggest that use of antiplatelet agents to prevent platelet deposition after PTA may not be useful for prevention of restenosis.
在92例接受高剂量或低剂量阿司匹林治疗的患者中，测定了外周动脉经皮腔内血管成形术（PTA）后血管成形部位血小板聚集的数量和时间进程，以及这些血小板对再狭窄的影响。通过双放射性示踪剂闪烁显像和计算血小板聚集指数（PAI）来定量血小板沉积。与随后几天相比，PTA后4 - 6小时PAI更高（P<0.05）。在有广泛夹层的血管中，血小板聚集有增加的趋势。两种剂量的阿司匹林治疗时，PTA部位均发生血小板聚集，两个剂量组之间无差异。在股腘段接受PTA的67例患者中，21例在中位随访14个月期间发生再狭窄。这21例患者在PTA后4 - 6小时和22 - 24小时的中位PAI显著低于46例未发生再狭窄的患者。数据表明，使用抗血小板药物预防PTA后血小板沉积可能对预防再狭窄无效。
