Horrocks M, Horrocks E H, Murphy P, Lane I F, Ruttley M S, Fligelstone L J, Watson H R
University Department of Surgery, Royal United Hospital, Bath, Bristol, UK.
Int Angiol. 1997 Jun;16(2):101-6.
To investigate the effects of two platelet inhibitors, aspirin and iloprost, on platelet uptake and restenosis at the site of angioplasty in patients undergoing femoral or popliteal angioplasty.
Prospective, open, randomised group comparison.
Two university hospitals.
43 patients undergoing femoral or popliteal angioplasty were randomised.
Patients received either aspirin (300 mg/day), iloprost (8 hours/day i.v. infusion) or no antiplatelet medication during angioplasty and on the subsequent two days.
Platelet uptake was measured using 111Indium-labelled platelets. Restenosis was assessed by repeat angiography at 3 months and clinical symptoms up to 12 months.
Median changes in platelet uptake were similar in the three treatment groups, but all platelet radioactivity ratios > 2.0 occurred in the control group. Restenosis at 3 months was observed in 3 control, 5 aspirin and 1 iloprost patient. Further surgical intervention was performed in 3 control and 3 aspirin patients, but in none of the iloprost patients up to 12 months after angioplasty.
Antiplatelet therapy may prevent large increases in platelet deposition at the angioplasty site, but the link between platelet deposition and restenosis was not substantiated in this study.
研究两种血小板抑制剂阿司匹林和伊洛前列素对接受股动脉或腘动脉血管成形术患者血管成形部位血小板摄取及再狭窄的影响。
前瞻性、开放性、随机分组比较。
两家大学医院。
43例接受股动脉或腘动脉血管成形术的患者被随机分组。
患者在血管成形术期间及随后两天接受阿司匹林（300毫克/天）、伊洛前列素（每天静脉输注8小时）或不接受抗血小板药物治疗。
使用铟111标记的血小板测量血小板摄取。在3个月时通过重复血管造影评估再狭窄情况，并观察长达12个月的临床症状。
三个治疗组血小板摄取的中位数变化相似，但对照组出现了所有血小板放射性比值>2.0的情况。3个月时，对照组有3例、阿司匹林组有5例、伊洛前列素组有1例出现再狭窄。血管成形术后12个月内，对照组有3例、阿司匹林组有3例患者接受了进一步的手术干预，但伊洛前列素组无患者接受此类干预。
抗血小板治疗可能会防止血管成形部位血小板沉积大幅增加，但本研究未证实血小板沉积与再狭窄之间的联系。
