Calderone Alberto, Licata Luana, Cesareni Gianni
Department of Biology, University of Rome Tor Vergata, Rome, Italy
Department of Biology, University of Rome Tor Vergata, Rome, Italy.
Nucleic Acids Res. 2015 Jan;43(Database issue):D588-92. doi: 10.1093/nar/gku830. Epub 2014 Sep 12.
Viral infections often cause diseases by perturbing several cellular processes in the infected host. Viral proteins target host proteins and either form new complexes or modulate the formation of functional host complexes. Describing and understanding the perturbation of the host interactome following viral infection is essential for basic virology and for the development of antiviral therapies. In order to provide a general overview of such interactions, a few years ago we developed VirusMINT. We have now extended the scope and coverage of VirusMINT and established VirusMentha, a new virus-virus and virus-host interaction resource build on the detailed curation protocols of the IMEx consortium and on the integration strategies developed for mentha. VirusMentha is regularly and automatically updated every week by capturing, via the PSICQUIC protocol, interactions curated by five different databases that are part of the IMEx consortium. VirusMentha can be freely browsed at http://virusmentha.uniroma2.it/ and its complete data set is available for download.
病毒感染常常通过干扰受感染宿主中的多个细胞过程而引发疾病。病毒蛋白靶向宿主蛋白，要么形成新的复合物，要么调节功能性宿主复合物的形成。描述和理解病毒感染后宿主相互作用组的扰动对于基础病毒学和抗病毒疗法的开发至关重要。为了提供此类相互作用的总体概述，几年前我们开发了VirusMINT。我们现在扩展了VirusMINT的范围和覆盖内容，并建立了VirusMentha，这是一个基于国际分子交换联盟（IMEx consortium）的详细编目协议以及为Mentha开发的整合策略构建的新的病毒-病毒和病毒-宿主相互作用资源。VirusMentha每周通过PSICQUIC协议定期自动更新，捕获由IMEx联盟的五个不同数据库策划的相互作用。可以在http://virusmentha.uniroma2.it/上免费浏览VirusMentha，其完整数据集可供下载。
