Chatr-aryamontri Andrew, Ceol Arnaud, Peluso Daniele, Nardozza Aurelio, Panni Simona, Sacco Francesca, Tinti Michele, Smolyar Alex, Castagnoli Luisa, Vidal Marc, Cusick Michael E, Cesareni Gianni
Department of Biology, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy.
Nucleic Acids Res. 2009 Jan;37(Database issue):D669-73. doi: 10.1093/nar/gkn739. Epub 2008 Oct 30.
Understanding the consequences on host physiology induced by viral infection requires complete understanding of the perturbations caused by virus proteins on the cellular protein interaction network. The VirusMINT database (http://mint.bio.uniroma2.it/virusmint/) aims at collecting all protein interactions between viral and human proteins reported in the literature. VirusMINT currently stores over 5000 interactions involving more than 490 unique viral proteins from more than 110 different viral strains. The whole data set can be easily queried through the search pages and the results can be displayed with a graphical viewer. The curation effort has focused on manuscripts reporting interactions between human proteins and proteins encoded by some of the most medically relevant viruses: papilloma viruses, human immunodeficiency virus 1, Epstein-Barr virus, hepatitis B virus, hepatitis C virus, herpes viruses and Simian virus 40.
要了解病毒感染对宿主生理的影响，需要全面了解病毒蛋白对细胞蛋白质相互作用网络所造成的扰动。VirusMINT数据库（http://mint.bio.uniroma2.it/virusmint/）旨在收集文献中报道的所有病毒与人类蛋白质之间的蛋白质相互作用。VirusMINT目前存储了超过5000种相互作用，涉及来自110多种不同病毒株的490多种独特病毒蛋白。通过搜索页面可以轻松查询整个数据集，结果可以用图形查看器显示。整理工作集中在报告人类蛋白质与某些医学上最相关病毒（乳头瘤病毒、人类免疫缺陷病毒1型、爱泼斯坦-巴尔病毒、乙型肝炎病毒、丙型肝炎病毒、疱疹病毒和猿猴病毒40）编码的蛋白质之间相互作用的手稿上。
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