Joint IRB-BSC Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), c/Baldiri Reixac 10-12, Barcelona 08028, Spain.
Curr Opin Struct Biol. 2013 Dec;23(6):929-40. doi: 10.1016/j.sbi.2013.07.005. Epub 2013 Jul 26.
Protein interaction maps are the key to understand the complex world of biological processes inside the cell. Public protein databases have already catalogued hundreds of thousands of experimentally discovered interactions, and struggle to curate all the existing information dispersed through the literature. However, to be most efficient, standard protocols need to be implemented for direct submission of new interaction sets directly into databases. At the same time, great efforts are invested to expand the coverage of the interaction space and unveil the molecular details of such interactions up to the atomistic level. The net result will be the definition of a detailed atlas spanning the universe of protein interactions to guide the everyday work of the biologist.
蛋白质相互作用图谱是理解细胞内复杂生物过程的关键。公共蛋白质数据库已经对数十万种实验发现的相互作用进行了编目，并努力整理通过文献分散的所有现有信息。然而，为了达到最高效率，需要实施标准协议，以便将新的相互作用集直接提交到数据库中。与此同时，还投入了大量精力来扩大相互作用空间的覆盖范围，并揭示这些相互作用的分子细节，直至原子水平。最终结果将是定义一个详细的图谱，涵盖蛋白质相互作用的整个宇宙，以指导生物学家的日常工作。
