Schneider D S, Zahka K G, Clark E B, Neill C A
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore.
Am J Dis Child. 1989 Mar;143(3):363-5. doi: 10.1001/archpedi.1989.02150150121030.
To determine if the pattern of cardiac care is affected by the presence of Down syndrome (DS) we analyzed the records of infants enrolled in the Baltimore-Washington Infant Study, a regional case-control study of congenital cardiovascular malformations. The age at cardiac diagnosis, the timing of cardiac surgery, and the one-year outcome were compared in 160 infants with DS and 540 infants with the same cardiac diagnoses but without chromosomal or other extracardiac anomalies (Isolated cardiovascular malformation [ICM] group). Cardiac referral and diagnosis were accomplished by 13 weeks of age in 78% of infants with DS and 67% of those with ICMs. However, by 26 weeks of age, the proportion of infants in both groups was comparable. Cardiac surgery was performed before 1 year of age in 99 of 160 infants with DS and in 141 of 540 infants with ICMs. The surgical outcome was similar in the two groups. We conclude that for defects of comparable severity, the pattern of cardiac care in the Baltimore-Washington, DC, area for infants with DS is timely and comparable to care for infants with ICMs.
为了确定唐氏综合征（DS）的存在是否会影响心脏护理模式，我们分析了参与巴尔的摩-华盛顿婴儿研究的婴儿记录，这是一项关于先天性心血管畸形的区域性病例对照研究。比较了160例患有DS的婴儿和540例患有相同心脏诊断但无染色体或其他心外异常（孤立性心血管畸形[ICM]组）的婴儿的心脏诊断年龄、心脏手术时间和一年的预后情况。78%患有DS的婴儿和67%患有ICM的婴儿在13周龄时完成了心脏转诊和诊断。然而，到26周龄时，两组婴儿的比例相当。160例患有DS的婴儿中有99例在1岁前接受了心脏手术，540例患有ICM的婴儿中有141例在1岁前接受了心脏手术。两组的手术结果相似。我们得出结论，对于严重程度相当的缺陷，华盛顿特区巴尔的摩地区患有DS的婴儿的心脏护理模式是及时的，且与患有ICM的婴儿的护理模式相当。
