Aquino A, Dòmini M, Rossi C, Sardella L, Palka G, Chiesa P L
Cattedra di Chirurgia Pediatrica and the Istituto di Genetica Medica, Università G.D'Annuzio di Pescara, Italy.
J Pediatr Surg. 1998 Sep;33(9):1380-2. doi: 10.1016/s0022-3468(98)90012-4.
This is a collaborative study carried out by Pediatric Surgeons of the "G.D'Annunzio" University and the Regional Association of Down Children of Abruzzo (Italy).
Data were collected of malformations combined with Down Syndrome (DS) during a 10-year period in a population of defined age to look for a possible improvement of the patients' life conditions. Reportedly, 50% of these patients may reach an age of about 60 years.
One hundred twenty-seven DS subjects from this region were evaluated, 54% of whom had associated malformations (13% cardiac, 41% extracardiac, and 13% both). Seventeen patients of 53 underwent surgery for extracardiac malformations, with gastrointestinal malformations prevailing. The largest number of DS babies were born from mothers under 30 years of age; this is attributed to the largest birth rate and the least prevention at this age. Mothers older than 38 years gave birth to DS babies with the lowest rate of associated malformations.
The role of the pediatric surgeon in multidisciplinary assistance for DS patients is stressed.
这是一项由“G. D'Annunzio”大学的儿科外科医生与意大利阿布鲁佐唐氏综合征患儿地区协会合作开展的研究。
收集了特定年龄人群在10年期间合并唐氏综合征（DS）的畸形数据，以探寻患者生活条件可能的改善情况。据报道，这些患者中有50%可能活到60岁左右。
对该地区的127名DS患者进行了评估，其中54%伴有相关畸形（13%为心脏畸形，41%为心外畸形，13%两者皆有）。53名患者中有17名因心外畸形接受了手术，其中胃肠道畸形最为常见。出生的DS婴儿中，数量最多的是30岁以下母亲所生；这归因于该年龄段最高的出生率和最少的预防措施。38岁以上的母亲所生DS婴儿伴有相关畸形的比例最低。
强调了儿科外科医生在为DS患者提供多学科援助中的作用。
