Wilberts B L, Arruda P H, Warneke H L, Erlandson K R, Hammer J M, Burrough E R
Department of Veterinary Pathology, Iowa State University, Ames, IA, USA.
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.
Res Vet Sci. 2014 Oct;97(2):341-7. doi: 10.1016/j.rvsc.2014.08.004. Epub 2014 Aug 27.
With the emergence of "Brachyspira hampsonii" associated with swine dysentery in North America, identification of effective treatments and interventions is a pressing need. Denagard® (tiamulin hydrogen fumarate) Liquid Concentrate 12.5% is approved in the United States for treatment of dysentery caused by Brachyspira hyodysenteriae at 0.006% in the water. In this study, the effectiveness of tiamulin in resolving clinical disease, eliminating viable spirochete shedding, and reducing neutrophilic colitis following infection with either "B. hampsonii" or B. hyodysenteriae was evaluated. Seventy-eight 7-week-old crossbred pigs were divided into three groups [sham-inoculated (n = 18), "B. hampsonii"-inoculated (n = 30), and B. hyodysenteriae-inoculated (n = 30)]. Each inoculum group was divided into three subgroups which received either 0.006% tiamulin, 0.018% tiamulin, or no medication. Both levels of tiamulin resolved clinical disease within 24 h of treatment initiation, eliminated spirochete shedding within 72 h of treatment initiation, and resolved and/or prevented histologic lesions in pigs infected with either Brachyspira spp.
随着北美出现与猪痢疾相关的“汉普森短螺旋体（Brachyspira hampsonii）”，确定有效的治疗方法和干预措施成为当务之急。在美国，12.5%的Denagard®（延胡索酸泰妙菌素）浓缩液被批准用于治疗由猪痢疾短螺旋体（Brachyspira hyodysenteriae）引起的痢疾，添加量为水中的0.006%。在本研究中，评估了泰妙菌素在解决临床疾病、消除活螺旋体排出以及减少感染“汉普森短螺旋体”或猪痢疾短螺旋体后嗜中性结肠炎方面的有效性。78头7周龄的杂交猪被分为三组[假接种组（n = 18）、“汉普森短螺旋体”接种组（n = 30）和猪痢疾短螺旋体接种组（n = 30）]。每个接种组又分为三个亚组，分别接受0.006%的泰妙菌素、0.018%的泰妙菌素或不接受药物治疗。两种浓度的泰妙菌素均在开始治疗后24小时内解决了临床疾病，在开始治疗后72小时内消除了螺旋体排出，并解决和/或预防了感染短螺旋体属的猪的组织学病变。
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