Bannon M J, Kelland M, Chiodo L A
Laboratory of Molecular Neurobiology, Sinai Research Institute, Detroit, Michigan.
J Neurochem. 1989 Mar;52(3):859-62. doi: 10.1111/j.1471-4159.1989.tb02533.x.
Electrical stimulation of the medial forebrain bundle, in a manner that augmented the release of dopamine in the forebrain, rapidly increased the striatal content of preproenkephalin (but not preprotachykinin) mRNA. This effect was mimicked by administration of either the indirect (dopamine-releasing) agonist methamphetamine or by the D-2 dopamine receptor agonist quinpirole, but not by the D-1 agonist SKF 38393. These data suggest that D-2 receptors, which mediate a stimulatory effect on enkephalin gene expression, may be subsaturated under basal conditions and, therefore, responsive to increases in synaptic dopamine.
以内侧前脑束电刺激的方式增强前脑多巴胺释放，可迅速增加脑啡肽原（而非速激肽原）mRNA的纹状体含量。给予间接（释放多巴胺）激动剂甲基苯丙胺或D-2多巴胺受体激动剂喹吡罗可模拟此效应，但D-1激动剂SKF 38393则不能。这些数据表明，介导对脑啡肽基因表达产生刺激作用的D-2受体在基础条件下可能未饱和，因此对突触多巴胺的增加有反应。
