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Dynamics of the recovery of releasable dopamine following electrical stimulation of the medial forebrain bundle.

作者信息

Michael A C, Ikeda M, Justice J B

出版信息

Neurosci Lett. 1987 Apr 23;76(1):81-6. doi: 10.1016/0304-3940(87)90196-0.

DOI:10.1016/0304-3940(87)90196-0
PMID:3495755
Abstract

In vivo voltammetry was used to monitor dopamine released into the extracellular fluid of the rat striatum by 10-s periods of electrical stimulation of nigrostriatal axons. By varying the interval between stimulations the dynamics of the recovery of the stimulation response has been investigated. The recovery is shown to be differentially affected by dopamine synthesis inhibition at short and long stimulation intervals. The recovery at less than 2 min is independent of dopamine synthesis. Processes in addition to dopamine synthesis must contribute to the recovery of the stimulation response.

摘要

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