Antel J P, Freedman M S, Brodovsky S, Francis G S, Duquette P
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada.
Ann Neurol. 1989 Feb;25(2):204-7. doi: 10.1002/ana.410250219.
Defective suppressor cell function has previously been demonstrated in patients with multiple sclerosis (MS) with progressive disease and moderate degrees of disability. In the present study activated suppressor cell function was assessed in patients with documented progressive disease who, at the time of study, had experienced severe disability (Kurtzke score greater than or equal to 6.5) for at least 2 years. We found that mean suppressor levels were significantly increased in this patient group compared with the suppressor levels in the MS patient group with progressive disease but only moderate disability (Kurtzke score of less than or equal to 6.0 within 2 years of study) (59 +/- 8% vs 19 +/- 7%, respectively, p less than 0.01). The mean value in the latter group was significantly reduced compared with the mean value for normal control subjects (47 +/- 4%, p less than 0.01), a finding consistent with previous reports. The results of this study indicate that suppressor cell function, as measured by our assay system, need not be defective in MS patients who have become severely disabled from the progressive form of the disease. Whether the patients who are now severely disabled from progressive MS passed through a phase of disease associated with the same suppressor defects as found in the progressive patients currently with moderate disability will remain speculative until long-term longitudinal studies are performed.
先前已证明，患有进展性疾病且有中度残疾的多发性硬化症（MS）患者存在抑制细胞功能缺陷。在本研究中，对有记录的进展性疾病患者进行了激活抑制细胞功能评估，这些患者在研究时已出现严重残疾（Kurtzke评分大于或等于6.5）至少2年。我们发现，与患有进展性疾病但只有中度残疾（研究2年内Kurtzke评分小于或等于6.0）的MS患者组相比，该患者组的平均抑制水平显著升高（分别为59±8%和19±7%，p<0.01）。与正常对照组的平均值相比，后一组的平均值显著降低（47±4%，p<0.01），这一发现与先前的报告一致。本研究结果表明，通过我们的检测系统测量，抑制细胞功能在因疾病进展而严重致残的MS患者中不一定存在缺陷。在进行长期纵向研究之前，目前因进展性MS而严重残疾的患者是否经历过与目前中度残疾的进展性患者相同的抑制缺陷相关疾病阶段仍有待推测。
