Noronha A, Toscas A, Jensen M A
Department of Neurology, University of Chicago, IL 60637.
Ann Neurol. 1990 Feb;27(2):207-10. doi: 10.1002/ana.410270219.
Suppressor cell function has been previously reported to be decreased in patients with progressive multiple sclerosis (MS). The abnormality could not be corrected in vitro and was present even after patients were treated with immunosuppressive agents. We now report that interferon beta augments suppressor cell function in vitro in progressive MS. Nonspecific suppressor cell function as measured in a concanavalin A (Con A) suppressor assay was reduced in 24 MS patients (mean percent suppression, 19.6 +/- 2.2) when compared to 19 normal subjects (mean percent suppression, 35.0 +/- 3.3). The data are highly significant (p less than 0.001). When recombinant human interferon beta (10(3) units/ml) was added to lymphocyte cultures with Con A, suppressor activity improved significantly. The mean percent suppression improved from 19.6 +/- 2.2 to 37.8 +/- 2.6 in MS (p less than 0.001) and from 35.0 +/- 3.3 to 46.2 +/- 3.5 (p less than 0.025) in control subjects. This study shows that recombinant interferon beta improves suppressor function in humans, an effect that is particularly significant in progressive MS.
先前有报道称，进行性多发性硬化症（MS）患者的抑制细胞功能会下降。这种异常在体外无法得到纠正，即使患者接受免疫抑制剂治疗后依然存在。我们现在报告，干扰素β在体外可增强进行性MS患者的抑制细胞功能。在刀豆蛋白A（Con A）抑制试验中所检测的非特异性抑制细胞功能，与19名正常受试者（平均抑制百分比为35.0±3.3）相比，24名MS患者的该功能降低（平均抑制百分比为19.6±2.2）。数据具有高度显著性（p＜0.001）。当将重组人干扰素β（10³单位/毫升）添加到含有Con A的淋巴细胞培养物中时，抑制活性显著改善。MS患者的平均抑制百分比从19.6±2.2提高到37.8±2.6（p＜0.001），对照受试者的平均抑制百分比从35.0±3.3提高到46.2±3.5（p＜0.025）。这项研究表明，重组干扰素β可改善人体的抑制功能，这一效应在进行性MS中尤为显著。
