Ewer Andrew K
University of Birmingham, Birmingham Women's Hospital, Edgbaston Birmingham UK.
Early Hum Dev. 2014 Sep;90 Suppl 2:S19-21. doi: 10.1016/S0378-3782(14)50006-0.
Pulse oximetry screening is a highly specific, moderately sensitive test for detecting critical congenital heart defects (CCHDs) that meets the criteria for universal screening. The possibility of using pulse oximetry as a screening test was first investigated over 10 years ago and since then data from more than 370,000 screened babies have now been published. There is significant heterogeneity in published screening protocols but almost all demonstrate that the addition of pulse oximetry screening reduces the 'diagnostic gap' - i.e. those babies with CCHD who are missed by existing screening methods and discharged from hospital before the diagnosis has been established. This review considers the available evidence and assesses the practical options for the introduction of pulse oximetry screening.
脉搏血氧饱和度筛查是一种用于检测严重先天性心脏病（CCHD）的高度特异性、中度敏感性的检测方法，符合通用筛查标准。早在10多年前就首次研究了将脉搏血氧饱和度作为筛查检测方法的可能性，自那时以来，现已发表了来自超过370,000名接受筛查婴儿的数据。已发表的筛查方案存在显著异质性，但几乎所有方案都表明，增加脉搏血氧饱和度筛查可缩小“诊断差距”，即那些患有严重先天性心脏病但被现有筛查方法漏诊并在确诊前出院的婴儿。本综述考虑了现有证据，并评估了引入脉搏血氧饱和度筛查的实际选择。
