Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.
Molecular Cancer Research, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands; Center for Molecular Medicine, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands; Cancer Genomics Netherlands, University Medical Center Utrecht, 3584 CG Utrecht, The Netherlands.
Trends Cell Biol. 2015 Jan;25(1):21-8. doi: 10.1016/j.tcb.2014.08.006. Epub 2014 Sep 11.
Error-free chromosome segregation relies on stable connections between kinetochores and spindle microtubules. The spindle assembly checkpoint (SAC) monitors such connections and relays their absence to the cell cycle machinery to delay cell division. The molecular network at kinetochores that is responsible for microtubule binding is integrated with the core components of the SAC signaling system. Molecular-mechanistic understanding of how the SAC is coupled to the kinetochore-microtubule interface has advanced significantly in recent years. The latest insights not only provide a striking view of the dynamics and regulation of SAC signaling events at the outer kinetochore but also create a framework for understanding how that signaling may be terminated when kinetochores and microtubules connect.
染色体正确分离依赖于动粒和纺锤体微管之间稳定的连接。纺锤体组装检查点（SAC）监控这些连接，并将其缺失情况传递给细胞周期机制，以延迟细胞分裂。负责微管结合的动粒上的分子网络与 SAC 信号系统的核心组件整合在一起。近年来，人们对 SAC 如何与动粒-微管界面偶联的分子机制有了显著的理解。最新的研究结果不仅提供了一个令人瞩目的视角，展示了外动粒处 SAC 信号事件的动态和调节，还为理解当动粒和微管连接时信号如何终止提供了一个框架。
