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肺移植免疫抑制——是时候采用新方法了？

Lung transplant immunosuppression - time for a new approach?

作者信息

Witt Chad A, Puri Varun, Gelman Andrew E, Krupnick Alexander Sasha, Kreisel Daniel

机构信息

Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.

出版信息

Expert Rev Clin Immunol. 2014 Nov;10(11):1419-21. doi: 10.1586/1744666X.2014.959499. Epub 2014 Sep 14.

DOI:10.1586/1744666X.2014.959499
PMID:25220652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4412736/
Abstract

Outcomes after lung transplantation remain worse compared to other solid organ transplants, which is in large part due to high rates of graft rejection. Despite emerging data that immune responses to lungs differ from other organs, immunosuppression for lung transplant recipients is still based on strategies established for recipients of other grafts. There exists an urgent need to develop immunosuppressive strategies for lung transplant recipients that take the unique immunological features of this organ into account.

摘要

与其他实体器官移植相比，肺移植后的结果仍然较差，这在很大程度上是由于移植排斥率较高。尽管有新的数据表明，对肺的免疫反应与其他器官不同，但肺移植受者的免疫抑制仍然基于为其他移植物受者制定的策略。迫切需要为肺移植受者制定免疫抑制策略，以考虑到该器官独特的免疫学特征。

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本文引用的文献

1
Long-term immunosuppression and malignancy in thoracic transplantation: where is the balance?胸外科移植中的长期免疫抑制与恶性肿瘤：平衡点在哪里？
J Heart Lung Transplant. 2014 May;33(5):461-7. doi: 10.1016/j.healun.2014.03.002. Epub 2014 Mar 12.
2
Renal transplantation using belatacept without maintenance steroids or calcineurin inhibitors.使用贝拉西普进行肾移植，无需维持使用类固醇或钙调神经磷酸酶抑制剂。
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3
A randomized, double-blind, placebo-controlled, multicenter study of rabbit ATG in the prophylaxis of acute rejection in lung transplantation.一项随机、双盲、安慰剂对照、多中心研究，评估兔抗胸腺细胞球蛋白在肺移植中预防急性排斥反应的效果。
Am J Transplant. 2014 May;14(5):1191-8. doi: 10.1111/ajt.12663. Epub 2014 Mar 11.
4
Central memory CD8+ T lymphocytes mediate lung allograft acceptance.中枢记忆 CD8+ T 淋巴细胞介导肺移植的接受。
J Clin Invest. 2014 Mar;124(3):1130-43. doi: 10.1172/JCI71359. Epub 2014 Feb 24.
5
The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Adult Lung and Heart-Lung Transplant Report--2013; focus theme: age.国际心肺移植学会登记处：第30份成人肺移植和心肺联合移植报告——2013年；重点主题：年龄
J Heart Lung Transplant. 2013 Oct;32(10):965-78. doi: 10.1016/j.healun.2013.08.007.
6
Acute antibody-mediated rejection after lung transplantation.肺移植后急性抗体介导的排斥反应。
J Heart Lung Transplant. 2013 Oct;32(10):1034-40. doi: 10.1016/j.healun.2013.07.004. Epub 2013 Aug 13.
7
Cutting edge: Pseudomonas aeruginosa abolishes established lung transplant tolerance by stimulating B7 expression on neutrophils.前沿：铜绿假单胞菌通过刺激中性粒细胞上的 B7 表达来消除已建立的肺移植耐受。
J Immunol. 2012 Nov 1;189(9):4221-5. doi: 10.4049/jimmunol.1201683. Epub 2012 Sep 26.
8
The Registry of the International Society for Heart and Lung Transplantation: 29th adult lung and heart-lung transplant report-2012.国际心肺移植学会登记处：2012年第29份成人肺移植和心肺联合移植报告
J Heart Lung Transplant. 2012 Oct;31(10):1073-86. doi: 10.1016/j.healun.2012.08.004.
9
Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: results of a prospective, randomized international trial in lung transplantation.他克莫司和环孢素对闭塞性细支气管炎综合征发展风险的影响不同：肺移植前瞻性、随机国际试验的结果。
J Heart Lung Transplant. 2012 Aug;31(8):797-804. doi: 10.1016/j.healun.2012.03.008. Epub 2012 May 2.
10
Lung transplant acceptance is facilitated by early events in the graft and is associated with lymphoid neogenesis.肺移植的接受是由移植物中的早期事件促成的，并与淋巴样新生有关。
Mucosal Immunol. 2012 Sep;5(5):544-54. doi: 10.1038/mi.2012.30. Epub 2012 May 2.