肺移植免疫抑制——是时候采用新方法了？
Lung transplant immunosuppression - time for a new approach?
作者信息
Witt Chad A, Puri Varun, Gelman Andrew E, Krupnick Alexander Sasha, Kreisel Daniel
机构信息
Department of Medicine, Washington University in St. Louis, St. Louis, MO, USA.
出版信息
Expert Rev Clin Immunol. 2014 Nov;10(11):1419-21. doi: 10.1586/1744666X.2014.959499. Epub 2014 Sep 14.
Abstract
Outcomes after lung transplantation remain worse compared to other solid organ transplants, which is in large part due to high rates of graft rejection. Despite emerging data that immune responses to lungs differ from other organs, immunosuppression for lung transplant recipients is still based on strategies established for recipients of other grafts. There exists an urgent need to develop immunosuppressive strategies for lung transplant recipients that take the unique immunological features of this organ into account.
摘要
与其他实体器官移植相比，肺移植后的结果仍然较差，这在很大程度上是由于移植排斥率较高。尽管有新的数据表明，对肺的免疫反应与其他器官不同，但肺移植受者的免疫抑制仍然基于为其他移植物受者制定的策略。迫切需要为肺移植受者制定免疫抑制策略，以考虑到该器官独特的免疫学特征。
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