Koljonen Virve, Åberg Fredrik, Rovasalo Aki, Mäkisalo Heikki
1 Division of Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki Finland, Institute of Clinical Medicine Helsinki University, Helsinki Finland. 2 Finnish Medical Society Duodecim, Helsinki, Finland.
Transplantation. 2015 Apr;99(4):867-72. doi: 10.1097/TP.0000000000000425.
The prevalence of alcohol use among Finnish liver transplant recipients has not been studied before.
We used self-report questionnaires and correlations between alcohol use liver biochemistry and depressive symptoms at the only transplant unit of the country, during a 6-month period in 2013.
The final study population consisted of 207 recipients. After verbal consent, participants filled in Alcohol Use Disorder Identification Test C and Beck Depression Inventory-II. Twenty percent of patients had been transplanted because of alcoholic liver disease. Of the patients, 43% reported alcohol use any time after liver transplantation (LT) and 28% during the past 1 month. Nearly all of those who received LT during childhood reported alcohol use more often and more drinks per occasion. Statistically significant risk factors for harmful drinking were male sex, age younger than 18 years at transplantation, and years from transplantation. Neither cause nor the depression scores reached statistical significance. Alcohol users had statistically significant higher liver biochemistry markers.
Our results revealed a 43% overall use of alcohol after LT and 28% use of alcohol within the last month and low depression scores. Among participants with alcohol liver disease origin, 39% and 34% any time and during the past 1 month, respectively, reported relapse. The alcohol consumption revealed in this study is similar to that of the general alcohol consumption tradition in Finland. Young males transplanted during their childhood were at most risk for harmful drinking.
此前尚未对芬兰肝移植受者的饮酒率进行过研究。
2013年，我们在该国唯一的移植单位，使用自我报告问卷，研究了饮酒与肝生化指标及抑郁症状之间的相关性，为期6个月。
最终研究人群包括207名受者。在获得口头同意后，参与者填写了酒精使用障碍识别测试C版和贝克抑郁量表第二版。20%的患者因酒精性肝病接受移植。在这些患者中，43%报告在肝移植（LT）后的任何时间饮酒，28%在过去1个月内饮酒。几乎所有在儿童期接受LT的患者报告饮酒频率更高，每次饮酒量更多。有害饮酒的统计学显著风险因素为男性、移植时年龄小于18岁以及移植后的年限。病因和抑郁评分均未达到统计学显著性。饮酒者的肝生化指标在统计学上显著更高。
我们的结果显示，LT后总体饮酒率为43%，过去1个月内饮酒率为28%，抑郁评分较低。在酒精性肝病起源的参与者中，分别有39%和34%报告在任何时间和过去1个月内复发。本研究中揭示的酒精消费量与芬兰一般酒精消费传统相似。儿童期接受移植的年轻男性有害饮酒风险最高。
