Nilsson T K, Tomic R, Ljungberg B
Department of Urology & Andrology, University of Umeå, Sweden.
Scand J Urol Nephrol. 1989;23(1):11-4. doi: 10.1080/00365599.1989.11690424.
In 18 patients, 12 with renal cell and 6 with prostatic carcinoma treatment with high dose medroxyprogesterone acetate (MPA) significantly increased serum antithrombin III and haptoglobin concentrations. During treatment the proteins correlated with each others suggesting a response to similar regulatory mechanisms. Levels of orosomucoid, a1-antitrypsin, C1-inhibitor and von Willebrand factor did not change during treatment showing that the increase of haptoglobin was not due to an acute-phase response. The increased antithrombin III levels may have a favourable impact on the frequency of thromboembolic complications during treatment with MPA.
在18例患者中，12例肾细胞癌患者和6例前列腺癌患者接受高剂量醋酸甲羟孕酮（MPA）治疗后，血清抗凝血酶III和触珠蛋白浓度显著升高。治疗期间，这些蛋白质相互关联，提示对相似调节机制有反应。血清类黏蛋白、α1-抗胰蛋白酶、C1-抑制剂和血管性血友病因子水平在治疗期间未发生变化，表明触珠蛋白升高并非由急性期反应所致。抗凝血酶III水平升高可能对MPA治疗期间血栓栓塞并发症的发生率产生有利影响。
