Düsing Rainer
Hypertoniezentrum Bonn , Germany.
Curr Med Res Opin. 2014 Dec;30(12):2423-4. doi: 10.1185/03007995.2014.965776. Epub 2014 Sep 29.
Although the need for combination therapy of hypertension was obvious from the early intervention trials, administration of such therapy as fixed-dose or single-pill combinations has only reached general acceptance in recent years. The main reason for this change of mind documented in the recommendation of using single-pill combinations in almost every recent hypertension guideline is our increasing knowledge about non-adherence to drug therapy. In the multifactorial origin of non-adherence, the complexity of therapy, especially in elderly patients with comorbidities and polypharmacy, has been identified as a major factor involved. So an important rule in hypertension treatment, and maybe in drug therapy in general, is to keep things as simple as possible.
尽管从早期干预试验中就明显看出高血压联合治疗的必要性，但固定剂量或单片复方制剂等联合治疗方案直到近年来才得到广泛认可。几乎所有最新高血压指南都推荐使用单片复方制剂，这种观念转变的主要原因是我们对药物治疗依从性的认识不断加深。在导致治疗依从性差的多因素中，治疗的复杂性，尤其是老年合并症患者和多种药物联合使用时的复杂性，已被确认为一个主要因素。因此，高血压治疗乃至一般药物治疗中的一个重要原则是尽量简化治疗方案。
