Dormehl I C, Van Wyk A, Pilloy W, Maree M, Knoesen O, De Winter R, Jacobs L, Hoppe H C
AEC Institute for Life Sciences, Medical Faculty, University of Pretoria, South Africa.
Am J Physiol Imaging. 1989;4(1):23-7.
In light of the high price of commercially available mercaptoacetyltriglycene (MAG3) it was decided to attempt a local MAG3-formation and to test this against diethylenetriamine pentaacetic acid (DTPA), 123I-Hippuran, and commercial MAG3 for diagnostic radiorenographic capabilities also in conjunction with furosemide and captopril. A baboon model (n = 6) was used, and the parameters evaluated were obtained by the "integral spleen" method of radiorenogram analysis. Although the images and parameters pointed to 123I-Hippuran and commercial MAG3 as the ideal renal scanning agents and to DTPA as the least so, with the local product an acceptable alternative, the differences were not significant enough to warrant either the purchase of the commercial product or the extensive development of the local product. Inexpensive 99mTc-DTPA in conjunction with modern computer techniques will probably supply most of the answers.
鉴于市售巯基乙酰三甘氨酸（MAG3）价格高昂，决定尝试进行本地MAG3的合成，并将其与二乙三胺五乙酸（DTPA）、123I-马尿酸、市售MAG3进行对比测试，以评估其在联合使用速尿和卡托普利时的放射性肾图诊断能力。使用了狒狒模型（n = 6），评估参数通过放射性肾图分析的“积分脾脏”方法获得。尽管图像和参数表明123I-马尿酸和市售MAG3是理想的肾脏扫描剂，而DTPA最不理想，本地产品是可接受的替代方案，但差异并不显著，不足以保证购买市售产品或大力开发本地产品。结合现代计算机技术的廉价99mTc-DTPA可能会提供大部分答案。
