Yang R, Lubek J E, Dyalram D, Liu X, Ord R A
Department of Oral and Maxillofacial Surgery, Oncology Program, Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA.
Department of Oral and Maxillofacial Surgery, Oncology Program, Greenebaum Cancer Center, University of Maryland, Baltimore, MD, USA.
Int J Oral Maxillofac Surg. 2014 Dec;43(12):1413-7. doi: 10.1016/j.ijom.2014.08.008. Epub 2014 Sep 13.
Should advanced age be a contraindication to the surgical management of head and neck cancer patients? A retrospective chart review was performed of patients aged ≥80 years treated surgically for a head and neck malignancy during the period 1996-2011 in a tertiary care cancer centre. The average follow-up was 32 months. Fifty-three patients were identified (mean age 85 years). Cardiovascular disease was the most prevalent co-morbidity (43%). Forty-five patients (85%) had oral cavity/oropharynx squamous cell carcinoma. Surgeries performed included 40 neck dissections and 12 microvascular free flaps. The average length of hospital stay (LOS) was 6.4 days. An increased LOS was significant in patients requiring free flap reconstruction (P<0.01). There were no perioperative deaths or free flap failures. The most common postoperative complications were cardiovascular (n=8), infection (n=10), and delirium (n=6). Thirty-four patients were discharged directly home. Free flap reconstruction did not adversely affect discharge disposition (P>0.05). More than 75% of patients did not report any major limitations to their activities of daily living. Major head and neck surgical procedures can be tolerated by patients of advanced age using careful patient selection. Age alone should not be a primary factor in the management of head and neck cancer patients.
高龄是否应作为头颈癌患者手术治疗的禁忌证?对1996年至2011年期间在一家三级护理癌症中心接受头颈恶性肿瘤手术治疗的80岁及以上患者进行了回顾性病历审查。平均随访时间为32个月。共确定了53例患者(平均年龄85岁)。心血管疾病是最常见的合并症(43%)。45例患者(85%)患有口腔/口咽鳞状细胞癌。所进行的手术包括40例颈部清扫术和12例游离微血管皮瓣移植术。平均住院时间(LOS)为6.4天。需要游离皮瓣重建的患者住院时间延长具有显著性(P<0.01)。没有围手术期死亡或游离皮瓣失败的情况。最常见的术后并发症是心血管疾病(n=8)、感染(n=10)和谵妄(n=6)。34例患者直接出院回家。游离皮瓣重建对出院处置没有不利影响(P>0.05)。超过75%的患者没有报告其日常生活活动有任何重大限制。通过仔细选择患者,高龄患者可以耐受主要的头颈外科手术。年龄本身不应成为头颈癌患者治疗的主要因素。