Tsunematsu Seiji, Natsuizaka Mitsuteru, Fujita Hiromi, Otsuka Noriyuki, Terashita Katsumi, Sato Fumiyuki, Kobayashi Tomoe, Nakai Masato, Tsukuda Yoko, Horimoto Hiromasa, Sho Takuya, Suda Goki, Nakanishi Mitsuru, Hashino Satoshi, Chuma Makoto, Sakamoto Naoya
Department of Gastroenterology and Hepatology, Hokkaido University, Graduate School of Medicine, Japan.
Intern Med. 2014;53(18):2079-82. doi: 10.2169/internalmedicine.53.2236. Epub 2014 Sep 15.
Hepatosplenic gamma-delta T-cell lymphoma (HSTCL) is a rare, aggressive subset of peripheral T-cell lymphoma. It has been reported that Epstein-Barr virus (EBV) infection can cause HSTCL; however, such cases are extremely rare, with only a few cases having been reported to date. We herein report an autopsy case of HSTCL associated with EBV infection. The presence of EBV infection was confirmed in serum EBV DNA and on in-situ hybridization, and cytotoxic molecules, such as granzyme B, perforin and T-cell intracytoplasmic antigen (TIA)-1, were all positive in lymphoma cells. These findings indicate that stimulation of persistent EBV infection may have caused HSTCL in this patient.
肝脾γδ T细胞淋巴瘤（HSTCL）是外周T细胞淋巴瘤中一种罕见的侵袭性亚型。据报道，爱泼斯坦-巴尔病毒（EBV）感染可导致HSTCL；然而，此类病例极为罕见，迄今为止仅有少数病例报道。我们在此报告一例与EBV感染相关的HSTCL尸检病例。血清EBV DNA及原位杂交均证实存在EBV感染，且淋巴瘤细胞中的细胞毒性分子，如颗粒酶B、穿孔素和T细胞胞浆内抗原（TIA）-1均呈阳性。这些发现表明，持续性EBV感染的刺激可能导致了该患者的HSTCL。
