4例日本患者的肝脾T细胞淋巴瘤病例。
Four hepatosplenic T-cell lymphoma cases of Japanese patients.
作者信息
Kawai Hidetsugu, Matsushita Hiromichi, Ohmachi Ken, Kojima Minoru, Machida Shinichiro, Ogawa Yoshiaki, Kawada Hiroshi, Nakamura Naoya, Ando Kiyoshi
机构信息
Department of Hematology/Oncology, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Department of Laboratory Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
出版信息
Leuk Res Rep. 2015 Dec 15;5:3-6. doi: 10.1016/j.lrr.2015.12.001. eCollection 2016.
Hepatosplenic T-cell lymphoma (HSTCL), a rare type of γδ T-cell lymphoma, is characterized by hepatosplenomegaly and cytopenias. It is associated with immunodeficiency and its age of onset is reportedly between the 20s and 30s. We herein report 4 Japanese HSTCL cases. Three of them, including an elderly case that was 74 years of age, were not at adolescence. No cases had a history of immunodeficiency. All other disease phenotypes were similar to the typical HSTCL cases. These findings suggest that there are a certain proportion of HSTCL patients who presented after middle age.
肝脾T细胞淋巴瘤（HSTCL）是一种罕见的γδ T细胞淋巴瘤，其特征为肝脾肿大和血细胞减少。它与免疫缺陷相关，据报道其发病年龄在20多岁至30多岁之间。我们在此报告4例日本HSTCL病例。其中3例，包括1例74岁的老年病例，并非处于青春期。所有病例均无免疫缺陷病史。所有其他疾病表型均与典型的HSTCL病例相似。这些发现表明，有一定比例的HSTCL患者在中年以后发病。
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