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POLE mutations as an alternative pathway for microsatellite instability in endometrial cancer: implications for Lynch syndrome testing.

作者信息

Konstantinopoulos Panagiotis A, Matulonis Ursula A

机构信息

Gynecologic Oncology Program, Dana-Farber Cancer Institute, Boston, Massachusetts.

出版信息

Cancer. 2015 Feb 1;121(3):331-4. doi: 10.1002/cncr.29057. Epub 2014 Sep 15.

DOI:10.1002/cncr.29057
PMID:25224324
Abstract
摘要

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POLE mutations as an alternative pathway for microsatellite instability in endometrial cancer: implications for Lynch syndrome testing.POLE突变作为子宫内膜癌微卫星不稳定性的另一条途径：对林奇综合征检测的意义。
Cancer. 2015 Feb 1;121(3):331-4. doi: 10.1002/cncr.29057. Epub 2014 Sep 15.
2
Polymerase ɛ (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch syndrome testing.子宫内膜癌中的聚合酶ɛ（POLE）突变：临床结局及对林奇综合征检测的意义
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Blinded histopathological characterisation of POLE exonuclease domain-mutant endometrial cancers: sheep in wolf's clothing.POLE 外切酶结构域突变型子宫内膜癌的盲法组织病理学特征：披着羊皮的狼。
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Gynecol Oncol. 2019 Jun;153(3):517-520. doi: 10.1016/j.ygyno.2019.03.100. Epub 2019 Mar 22.

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PD-L1 and CD4 are independent prognostic factors for overall survival in endometrial carcinomas.PD-L1 和 CD4 是子宫内膜癌患者总生存的独立预后因素。
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Polymerase ε (POLE) ultra-mutation in uterine tumors correlates with T lymphocyte infiltration and increased resistance to platinum-based chemotherapy in vitro.子宫肿瘤中的聚合酶ε（POLE）超突变与T淋巴细胞浸润以及体外对铂类化疗药物耐药性增加相关。
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