p16和p27在尿路上皮癌中的表达及其预后价值。
Expressions of p16 and p27 in urothelial carcinoma and their prognostic value.
作者信息
Yang Ching-Hsiu, Wu Chun-Chieh, Chen Wan-Tzu, Chai Chee-Yin, Yang Sheau-Fang
机构信息
Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan.
Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung City, Taiwan; Department of Pathology, Kaohsiung Medical University, Kaohsiung City, Taiwan.
出版信息
Kaohsiung J Med Sci. 2014 Sep;30(9):453-8. doi: 10.1016/j.kjms.2014.05.003. Epub 2014 Jun 22.
Expressions of human p16 and p27 were tested for correlations with clinicopathologic features of urothelial carcinoma (UC). Tissue microarrays (TMA) constructed from paraffin-embedded specimens from 78 patients with UC were analyzed by immunohistochemical staining. In 49 of the 78 tumors (63%), high p16 expression was associated with absence of tumor invasiveness and low-grade carcinoma (p = 0.003 and p = 0.046, respectively). The p27 expression was high in 33 of the 78 tumors (42%) and showed a significant negative association with invasiveness, carcinoma grade, and tumor size (p = 0.016, p = 0.046, and p = 0.014, respectively). Kaplan-Meier analysis indicated that patients with high p27 levels had longer than average overall survival (p = 0.021). This study demonstrates that p16 and p27 are prognostic indicators of tumor stage and grade in UC and that they provide clinicians with the ancillary information needed for selecting suitable therapeutic strategies.
检测人p16和p27的表达与尿路上皮癌（UC）临床病理特征的相关性。采用免疫组织化学染色分析由78例UC患者石蜡包埋标本构建的组织芯片（TMA）。在78例肿瘤中的49例（63%）中，p16高表达与无肿瘤侵袭及低级别癌相关（分别为p = 0.003和p = 0.046）。78例肿瘤中的33例（42%）p27表达高，且与侵袭性、癌分级和肿瘤大小呈显著负相关（分别为p = 0.016、p = 0.046和p = 0.014）。Kaplan-Meier分析表明，p27水平高的患者总生存期长于平均生存期（p = 0.021）。本研究表明，p16和p27是UC肿瘤分期和分级的预后指标，可为临床医生选择合适的治疗策略提供所需的辅助信息。
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