Hollis Fiona, Kabbaj Mohamed
ILAR J. 2014;55(2):221-32. doi: 10.1093/ilar/ilu002.
Depression is one of the most disabling medical conditions in the world today, yet its etiologies remain unclear and current treatments are not wholly effective. Animal models are a powerful tool to investigate possible causes and treatments for human diseases. We describe an animal model of social defeat as a possible model for human depression. We discuss the paradigm, behavioral correlates to depression, and potential underlying neurobiological mechanisms with an eye toward possible future therapies.
抑郁症是当今世界最具致残性的医学病症之一，但其病因仍不明确，目前的治疗方法也并非完全有效。动物模型是研究人类疾病可能病因和治疗方法的有力工具。我们描述一种社会挫败动物模型，作为人类抑郁症的一种可能模型。我们讨论该模型、与抑郁症相关的行为以及潜在的神经生物学机制，着眼于未来可能的治疗方法。
