Huhman Kim L
Department of Psychology, P.O. Box 3966, Center for Behavioral Neuroscience, Georgia State University, Atlanta, GA 30302-3966, USA.
Horm Behav. 2006 Nov;50(4):640-6. doi: 10.1016/j.yhbeh.2006.06.022. Epub 2006 Jul 25.
Social conflict models have been proposed as a powerful way to investigate basic questions of how brain and behavior are altered by social experience. Social defeat, in particular, appears to be a major stressor for most species, and in humans, this stressor is thought to play an important role in the onset of a variety of psychiatric disorders including depression and post-traumatic stress disorder. Aggressive experience, on the other hand, may promote disorders involving inappropriate aggression and violence. Current research using animal models of social conflict involves multiple levels of analysis from genetic and molecular to systems and overt behavior. This review briefly examines a variety of these animal models of social conflict in order to assess whether they are useful for advancing our understanding of how experience can shape brain and behavior and for translating this information so that we have the potential to improve the quality of life of individuals with mental illness and behavioral disorders.
社会冲突模型已被提出，作为一种强有力的方式来研究大脑和行为如何因社会经历而改变的基本问题。特别是社会挫败，似乎对大多数物种来说都是一个主要的应激源，而在人类中，这种应激源被认为在包括抑郁症和创伤后应激障碍在内的多种精神疾病的发病过程中起着重要作用。另一方面，攻击性经历可能会引发涉及不适当攻击和暴力的疾病。目前使用社会冲突动物模型的研究涉及从基因和分子到系统及明显行为的多个分析层面。这篇综述简要考察了多种此类社会冲突动物模型，以评估它们是否有助于增进我们对经历如何塑造大脑和行为的理解，以及是否有助于转化这些信息，从而使我们有可能提高患有精神疾病和行为障碍个体的生活质量。
