Esha das Gupta, Department of Medicine, International Medical University, Jalan Rasah, 70300 Seremban, Negeri Sembilan, Malaysia.
Huey Shin Tee, Department of Medicine, International Medical University, Jalan Rasah, 70300 Seremban, Negeri Sembilan, Malaysia.
Pak J Med Sci. 2014 Sep;30(5):976-81. doi: 10.12669/pjms.305.5112.
The main objective of this study was to determine the predictors of frequent oral analgesic use among Rheumatoid Arthritis (RA) patients who were prescribed with the above medication on an 'as-needed' basis.
Patients with RA were recruited consecutively from the Rheumatology outpatient clinics in this cross-sectional study. The sociodemographic data, frequency of oral analgesic intake, Patient Global Assessment (PGA) scores and HAQ (Health Assessment Questionnaire) scores were determined by interviewing the subjects. Subjects were divided into 2 groups; frequent users (3 days and above in a week) and less frequent users (less than 3 days in a week).
In a total of 112 subjects, 39 (34.8%) were frequent analgesic users. Both the HAQ and PGA scores were significantly higher among the frequent users (p<0.05). Using multivariate analysis, the HAQ scores (p=0.015, odds ratio 3.161 [95% confidence interval of 1.246-8.015]) and PGA scores (p=0.039 odds ratio 1.291 [95% confidence interval of 1.012-1.646]) were found to be independent predictors of frequent analgesic use.
Our study confirms that the frequency of analgesic intake in Rheumatoid Arthritis has a significant relationship with patient-reported functional capacity and well being.
本研究的主要目的是确定类风湿关节炎（RA）患者在按需服用上述药物的情况下频繁使用口服镇痛药的预测因素。
在这项横断面研究中，连续招募来自风湿病门诊的 RA 患者。通过访谈受试者确定社会人口统计学数据、口服镇痛药摄入频率、患者总体评估（PGA）评分和 HAQ（健康评估问卷）评分。受试者分为两组：频繁使用者（每周 3 天及以上）和不频繁使用者（每周少于 3 天）。
在总共 112 名受试者中，有 39 名（34.8%）是频繁使用镇痛药者。频繁使用者的 HAQ 和 PGA 评分均显著升高（p<0.05）。使用多变量分析，HAQ 评分（p=0.015，优势比 3.161[95%置信区间 1.246-8.015]）和 PGA 评分（p=0.039，优势比 1.291[95%置信区间 1.012-1.646]）被发现是频繁使用镇痛药的独立预测因素。
我们的研究证实，类风湿关节炎患者镇痛药的摄入频率与患者报告的功能能力和健康状况有显著关系。
