Department of Chemical and Biological Engineering, Chalmers University of Technology , Gothenburg , Sweden.
Front Bioeng Biotechnol. 2014 Sep 1;2:32. doi: 10.3389/fbioe.2014.00032. eCollection 2014.
Volatile energy costs and environmental concerns have spurred interest in the development of alternative, renewable, sustainable, and cost-effective energy resources. Environment-friendly processes involving microbes can be used to synthesize advanced biofuels. These fuels have the potential to replace fossil fuels in supporting high-power demanding machinery such as aircrafts and trucks. From an engineering perspective, the pathway for fatty acid biosynthesis is an attractive route for the production of advanced fuels such as fatty acid ethyl esters, fatty alcohols, and alkanes. The robustness and excellent accessibility to molecular genetics make the yeast Saccharomyces cerevisiae a suitable host for the purpose of bio-manufacturing. Recent advances in metabolic engineering, as well as systems and synthetic biology, have now provided the opportunity to engineer yeast metabolism for the production of fatty acid-derived fuels and chemicals.
挥发性能源成本和环境问题促使人们关注开发替代的、可再生的、可持续的和具有成本效益的能源资源。涉及微生物的环保工艺可用于合成先进的生物燃料。这些燃料有可能替代化石燃料，为飞机和卡车等大功率需求的机械提供支持。从工程学的角度来看，脂肪酸生物合成途径是生产高级燃料的有吸引力的途径，如脂肪酸乙酯、脂肪醇和烷烃。酵母酿酒酵母的稳健性和极好的分子遗传学可及性使其成为生物制造的合适宿主。最近在代谢工程以及系统和合成生物学方面的进展，为工程酵母代谢以生产脂肪酸衍生的燃料和化学品提供了机会。
