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[Lethal and mutagenic effect of incorporated 6-3H-pyrimidines on extracellular phage lambda].

作者信息

Konevega L V, Kalinin V L

出版信息

Radiobiologiia. 1989 Jan-Feb;29(1):17-22.

PMID:2522663
Abstract

A study was made of lethal and mutagenic effects of 6-3H-thymidine and 6-3H-cytosine, incorporated into DNA, on extracellular phage lambda. The lethal effects of both 6-3H-pyrimidines (the number of lethal hits per 3H decay) do not differ from those of [3H-methyl]thymidine and 5-3H-cytosine. The mutagenic effects (at equal survival rates) are as follows: 6-3H-thymidine approximately 3H2O less than [3H-methyl]thymidine less than 6-3H-cytosine less than 5-3H-cytosine. UV-irradiation of host cells induces a more pronounced W-mutagenesis with 6-3H-cytosine than with 6-3H-thymidine.

摘要

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