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[氚水和掺入的[3H-甲基]胸腺嘧啶对细胞外噬菌体λ的致死和诱变活性]

[Lethal and mutagenic activity of tritiated water and incorporated [3H-methyl]-thymidine on extracellular phage lambda].

作者信息

Konevega L V, Kalinin V L

出版信息

Radiobiologiia. 1984 Mar-Apr;24(2):167-72.

PMID:6233629
Abstract

A study was made of lethal and mutagenic effects on extracellular phage lambda of beta-particles from tritiated water and of [3H-methyl]-thymidine incorporated into DNA. It was shown that the mean lethal dose D10 and the yield of c-mutations per unit of the dose absorbed during external beta-irradiation in 3H2O or during the decay of incorporated [3H-methyl]-thymidine were equivalent to those obtained during 60Co-gamma-irradiation in 4% nutrient broth or at a dried state respectively.

摘要

研究了氚水的β粒子以及掺入DNA中的[3H-甲基]胸腺嘧啶核苷对细胞外噬菌体λ的致死和诱变作用。结果表明,在3H2O中进行外部β辐射或在掺入的[3H-甲基]胸腺嘧啶核苷衰变期间,平均致死剂量D10和每吸收单位剂量的c突变产率,分别相当于在4%营养肉汤中进行60Co-γ辐射或处于干燥状态时获得的结果。

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