Newsom Sean A, Schenk Simon
Division of Endocrinology, Metabolism and Diabetes, University of Colorado School of Medicine, Aurora, Colo., USA.
Med Sport Sci. 2014;60:62-70. doi: 10.1159/000357336. Epub 2014 Sep 9.
This chapter summarizes current knowledge regarding the interaction between lipid availability, endurance exercise, and insulin sensitivity. We discuss the role of lipid availability as a key mediator of insulin resistance in obesity, the proposed cellular mechanisms underlying this relationship, recent studies demonstrating that acute exercise protects against lipid-induced insulin resistance, how fatty acid partitioning may contribute to this protective effect of endurance exercise and finally remaining questions and future directions in the field.
本章总结了关于脂质可利用性、耐力运动和胰岛素敏感性之间相互作用的当前知识。我们讨论了脂质可利用性作为肥胖中胰岛素抵抗关键调节因子的作用、这种关系背后的细胞机制、近期研究表明急性运动可预防脂质诱导的胰岛素抵抗、脂肪酸分配如何促进耐力运动的这种保护作用，以及该领域尚存的问题和未来方向。
