Lange Sara S, Novetsky Akiva P, Powell Matthew A
Division of Medical Oncology, Washington University, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
Division of Gynecologic Oncology, Washington University, 660 S. Euclid Ave., St. Louis, MO 63110, USA.
Discov Med. 2014 Sep;18(98):133-40.
Uterine sarcomas are a heterologous group of rare malignancies accounting for 8-10% of all uterine malignancies, but are significantly more aggressive and have worse prognoses. Management of uterine sarcomas including leiomyosarcoma and endometrial stromal sarcoma are reviewed here, with additional discussions regarding high-grade undifferentiated sarcoma and adenosarcoma. Uterine carcinosarcomas are currently staged and treated similar to high-grade epithelial endometrial carcinomas, thus will not be discussed in this review. Gemcitabine/docetaxel with adriamycin holds promise for the treatment of leiomyosarcoma, but currently, limited advancements have been made in discovering targeted therapies to these tumors. Continued translational research in both medical oncology and gynecologic oncology is necessary to forward the development of novel and targeted therapeutic agents in the treatment of sarcoma. Enrollment of these patients in clinical trials is encouraged, and will allow for the development of safer and more effective therapies.
子宫肉瘤是一组异质性罕见恶性肿瘤，占所有子宫恶性肿瘤的8 - 10%，但侵袭性更强，预后更差。本文综述了子宫肉瘤（包括平滑肌肉瘤和子宫内膜间质肉瘤）的治疗，并对高级别未分化肉瘤和腺肉瘤进行了额外讨论。子宫癌肉瘤目前的分期和治疗与高级别上皮性子宫内膜癌相似，因此本综述将不对此进行讨论。吉西他滨/多西他赛联合阿霉素有望用于治疗平滑肌肉瘤，但目前在发现针对这些肿瘤的靶向治疗方面进展有限。医学肿瘤学和妇科肿瘤学持续的转化研究对于推动肉瘤治疗中新型靶向治疗药物的开发至关重要。鼓励这些患者参加临床试验，这将有助于开发更安全、更有效的治疗方法。
