管理霍奇金淋巴瘤青少年和青年患者的挑战方面。

The challenging aspects of managing adolescents and young adults with Hodgkin's lymphoma.

机构信息

First Department of Internal Medicine, German Hodgkin Study Group, University of Cologne, Cologne, Germany.

出版信息

Acta Haematol. 2014;132(3-4):274-8. doi: 10.1159/000360205. Epub 2014 Sep 10.

Abstract

Cancer in the adolescent and young adult (AYA) is the second leading cause of nonaccidental death with hematological malignancies spiking during this period. Treatment of AYAs with hematological malignancies usually follows either pediatric or adult protocols with sufficient information lacking on subgroup analyses regarding course and outcome. In this review we will outline up-to-date treatment possibilities for AYAs diagnosed with Hodgkin's lymphoma. Early and late toxicities will be addressed and future directions of research suggested.

摘要

青少年和年轻成人（AYA）的癌症是第二大致非意外死亡的原因，在此期间血液系统恶性肿瘤的发病率上升。AYA 血液系统恶性肿瘤的治疗通常遵循儿科或成人方案，但关于亚组分析的病程和结果，信息仍然不足。在这篇综述中，我们将概述诊断为霍奇金淋巴瘤的 AYA 的最新治疗可能性。将讨论早期和晚期毒性，并提出未来的研究方向。