Pratt D A, Miller W R, Dawes J
MRC/SNBTS Blood Components Assay Group, Edinburgh, U.K.
Eur J Cancer Clin Oncol. 1989 Feb;25(2):343-50. doi: 10.1016/0277-5379(89)90028-x.
Cytosols of malignant breast tissue contained significantly higher levels of thrombospondin (TSP) and von Willebrand factor (vWF) than non-malignant breast. TSP and vWF content of human breast were significantly correlated whereas there was no correlation between TSP and the platelet-specific protein beta-thromboglobulin (beta TG). Whilst TSP in pre-menopausal breast cancer was slightly lower than in post-menopausal breast cancer, it did not correlate with oestrogen receptors (ER) or progesterone receptors (PR), but was negatively correlated with tissue-type plasminogen activator (tPA), an oestradiol-inducible enzyme. Secretion of TSP by MCF-7 cells was low and refractory to hormones. High levels of TSP appeared to be associated with the centre of the tumour mass. It is suggested that activation of the endothelium may be responsible, at least in part, for the high levels of TSP found in malignant breast tissue and could be a factor in the growth and spread of breast cancer.
恶性乳腺组织的细胞溶胶中血小板反应蛋白（TSP）和血管性血友病因子（vWF）的水平显著高于非恶性乳腺组织。人乳腺中TSP和vWF的含量显著相关，而TSP与血小板特异性蛋白β-血小板球蛋白（βTG）之间无相关性。虽然绝经前乳腺癌中的TSP略低于绝经后乳腺癌，但它与雌激素受体（ER）或孕激素受体（PR）无关，而是与组织型纤溶酶原激活物（tPA，一种雌二醇诱导酶）呈负相关。MCF-7细胞分泌TSP的水平较低且对激素不敏感。高水平的TSP似乎与肿瘤块的中心有关。提示内皮细胞的激活可能至少部分地导致了恶性乳腺组织中TSP的高水平，并且可能是乳腺癌生长和扩散的一个因素。
