Intracellular retention of the extracellular domain of the (pro)renin receptor in mammalian cells.
作者信息
Suzuki-Nakagawa Chiharu, Nishimura Misa, Noda Masako, Iwata Hideyuki, Hattori Masaru, Ebihara Akio, Suzuki Fumiaki, Nakagawa Tsutomu
机构信息
a The United Graduate School of Agricultural Sciences, Gifu University , Gifu , Japan.
出版信息
Biosci Biotechnol Biochem. 2014;78(7):1187-90. doi: 10.1080/09168451.2014.915732. Epub 2014 May 28.
As a component of the renin-angiotensin system, the (pro)renin receptor [(P)RR] activates prorenin along with intracellular signaling pathways. In this study, the glutathione S-transferase-fused extracellular domain of (P)RR expressed in mammalian cells was recovered in the detergent phase in detergent-based two-phase separation experiments, and intracellular localization was observed by immunocytochemistry, suggesting retention inside the cell through stable membrane association.
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