海洋海绵 Monanchora sp. 中的细胞毒性 5α,8α-表二氧甾醇

Cytotoxic 5α,8α-epidioxy sterols from the marine sponge Monanchora sp.

机构信息

Center for Marine Natural Products and Drug Discovery, School of Earth and Environmental Sciences, Seoul National University, NS-80, Seoul, 151-747, Republic of Korea.

出版信息

Arch Pharm Res. 2015 Jan;38(1):18-25. doi: 10.1007/s12272-014-0480-8. Epub 2014 Sep 19.

DOI:10.1007/s12272-014-0480-8

PMID:25231340

Abstract

Three new sterols, 5α,8α-epidioxy-24-norcholesta-6,9(11),22-trien-3β-ol (1), 5α,8α-epidioxy-cholesta-6,9(11),24-trien-3β-ol (2), and 5α,8α-epidioxy-cholesta-6,23-dien-3β,25-diol (3), with four known sterols (4-7) were isolated from a marine sponge Monanchora sp. Their chemical structures were elucidated by extensive spectroscopic analysis. Compounds 1 and 3-7 showed moderate cytotoxicity against several human carcinoma cell lines including renal (A-498), pancreatic (PANC-1 and MIA PaCa-2), and colorectal (HCT 116) cancer cell lines.

摘要

从海洋海绵 Monanchora sp. 中分离得到三个新甾醇，5α,8α-表二氧代-24-降胆甾-6,9(11),22-三烯-3β-醇（1）、5α,8α-表二氧代-胆甾-6,9(11),24-三烯-3β-醇（2）和 5α,8α-表二氧代-胆甾-6,23-二烯-3β,25-二醇（3），以及四个已知甾醇（4-7）。通过广泛的光谱分析阐明了它们的化学结构。化合物 1 和 3-7 对几种人癌细胞系具有中等的细胞毒性，包括肾（A-498）、胰腺（PANC-1 和 MIA PaCa-2）和结肠直肠（HCT 116）癌细胞系。