来自海洋海绵霍氏海绵属物种的5,6:8,9-二环氧及其他细胞毒性甾醇

5,6:8,9-diepoxy and other cytotoxic sterols from the marine sponge Homaxinella sp.

作者信息

Mansoor Tayyab A, Lee Yoon Mi, Hong Jongki, Lee Chong-O, Im Kwang Sik, Jung Jee H

机构信息

College of Pharmacy, Pusan National University, Busan 609-735, Korea.

出版信息

J Nat Prod. 2006 Jan;69(1):131-4. doi: 10.1021/np0502950.

DOI:10.1021/np0502950

PMID:16441084

Abstract

Four new (1, 2, 4, and 5) and 14 known (3 and 6-18) polyoxygenated sterols have been isolated from the MeOH extract of the marine sponge Homaxinella sp. by bioactivity-guided fractionation. The planar structures of the sterols were established by 1D and 2D NMR and MS spectroscopic analysis. 5,6:8,9-Diepoxy sterols (1-3) were isolated from a marine organism for the first time. The isolated sterols were tested against a panel of five human solid tumor cell lines and exhibited varying degrees of cytotoxicity.

摘要

通过生物活性导向分级分离，从海洋海绵Homaxinella sp.的甲醇提取物中分离出了4种新的（1、2、4和5）和14种已知的（3和6 - 18）多氧化甾醇。通过一维和二维核磁共振以及质谱光谱分析确定了这些甾醇的平面结构。5,6:8,9 - 二环氧甾醇（1 - 3）首次从海洋生物中分离得到。对分离出的甾醇针对一组5种人类实体瘤细胞系进行了测试，结果显示出不同程度的细胞毒性。