血清 CA724 水平下降可能是预测晚期胃癌化疗中肿瘤应答的一个因素。
Decline of serum CA724 as a probable predictive factor for tumor response during chemotherapy of advanced gastric carcinoma.
机构信息
1 Department of Oncology, 2 Department of Thoracic Surgery, Yancheng City No. 1 People's Hospital, Yancheng 224000, China.
出版信息
Chin J Cancer Res. 2014 Aug;26(4):404-9. doi: 10.3978/j.issn.1000-9604.2014.07.02.
OBJECTIVE
To evaluate the predictive value of decline in the serum level of carbohydrate antigen 724 (CA724) on tumor response during the chemotherapy in patients with advanced gastric carcinoma (GC).
METHODS
The serum CA724 level was determined by electrochemiluminescence immunoassay, while the objective response rate (ORR) was assessed according to response evaluation criteria in solid tumors (RECIST). The association of the changes of serum concentration of CA724 with ORR was analyzed.
RESULTS
The ORR in CA724 (pretreatment serum level) high and low groups was 32.3% (20/62) and 52.8% (19/36), respectively (P=0.045). The relationship between the reduction of CA724 and the ORR was statistically significant (P=0.044). Receiver operating characteristic (ROC) curve established the best cutoff value of the decrease ratio of CA724 as 20.5%.
CONCLUSIONS
CA724 decline seems to indicate chemotherapy efficacy in patients with advanced GC, and an average drop of 20.5% in serum CA724 appears to predict the sensitivity to chemotherapy.
目的
评估晚期胃癌患者化疗过程中血清碳水化合物抗原 724（CA724）水平下降对肿瘤反应的预测价值。
方法
采用电化学发光免疫分析法测定血清 CA724 水平，根据实体瘤反应评价标准（RECIST）评估客观缓解率（ORR）。分析血清 CA724 浓度变化与 ORR 的相关性。
结果
CA724（治疗前血清水平）高组和低组的 ORR 分别为 32.3%（20/62）和 52.8%（19/36）（P=0.045）。CA724 下降与 ORR 之间存在统计学关联（P=0.044）。绘制受试者工作特征（ROC）曲线确定 CA724 下降率的最佳截断值为 20.5%。
结论
CA724 下降似乎预示着晚期 GC 患者的化疗疗效，血清 CA724 平均下降 20.5%可能预测对化疗的敏感性。
Zotero 插件