ABO血型与食管鳞状细胞癌患者的总生存期之间是否存在关联？
Is there an association between ABO blood group and overall survival in patients with esophageal squamous cell carcinoma?
作者信息
Yang Xun, Huang Ying, Feng Ji-Feng
机构信息
Department of Thoracic Surgery, Zhejiang Cancer Hospital No. 38 Guangji Road, Banshan Bridge, Hangzhou 310022, China.
Department of Operating Theatre, Zhejiang Cancer Hospital No. 38 Guangji Road, Banshan Bridge, Hangzhou 310022, China.
出版信息
Int J Clin Exp Med. 2014 Aug 15;7(8):2214-8. eCollection 2014.
BACKGROUND
The relationship between ABO blood group and clinical characteristics had been studied in several cancers. However, its role in esophageal cancer (EC) is unclear. The aim of this study was to determine whether ABO blood group is associated with overall survival in patients with esophageal squamous cell carcinoma (ESCC).
METHODS
From 2005 to 2008, a retrospective analysis of 496 consecutive patients with ESCC was conducted. The relationship between ABO blood group and clinicopathologic features of ESCC was analyzed. Prognostic factors for overall survival of ESCC were also analyzed.
RESULTS
The 5-year overall survival of ESCC patients with blood group A, B, AB and O were 47.8%, 44.1%, 43.2%, and 38.4%, respectively (P = 0.165). However, patients with blood group non-O have a better 5-year overall survival than patients with blood group O (45.7% vs. 38.4%; P = 0.043). Multivariate analyses showed ABO blood group (O vs. non-O; P = 0.034) is an independent prognostic factors.
CONCLUSIONS
ABO blood group is associated with overall survival in patients with ESCC. We concluded that patients with blood group O have a significantly worse overall survival than non-O blood groups.
背景
ABO血型与几种癌症的临床特征之间的关系已得到研究。然而，其在食管癌（EC）中的作用尚不清楚。本研究的目的是确定ABO血型是否与食管鳞状细胞癌（ESCC）患者的总生存期相关。
方法
对2005年至2008年连续收治的496例ESCC患者进行回顾性分析。分析ABO血型与ESCC临床病理特征之间的关系。还分析了ESCC总生存期的预后因素。
结果
A、B、AB和O血型的ESCC患者5年总生存率分别为47.8%、44.1%、43.2%和38.4%（P = 0.165）。然而，非O血型患者的5年总生存率高于O血型患者（45.7%对38.4%；P = 0.043）。多因素分析显示ABO血型（O型与非O型；P = 0.034）是一个独立的预后因素。
结论
ABO血型与ESCC患者的总生存期相关。我们得出结论，O血型患者的总生存期明显低于非O血型患者。
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