富含亮氨酸重复激酶2的突变与中国帕金森病患者的非运动症状无关。
Mutant of leucine-rich repeat kinase 2 is not associated with non-motor symptoms in Chinese Parkinson's disease patients.
作者信息
Hao Maolin, Pan Ning, Zhang Qinghua, Wang Xiaohong
机构信息
Department of Neurology, Provincial Hospital Affiliated to Shandong University Jinan 250022, Shandong, China.
出版信息
Int J Clin Exp Med. 2014 Aug 15;7(8):2253-7. eCollection 2014.
Non-motor symptoms (NMS) are common in patients with Parkinson's disease (PD). However, little is known about NMS in patients with mutant of leucine-rich repeat kinase 2 (LRRK2). This study aimed to elucidate the relationship between NMS in Chinese PD patients and to ascertain if there were differences in NMS between PD patients and mutant of LRRK2. 200 sporadic PD (sPD) patients were recruited from a Provincial Hospital Affiliated to Shandong University. The Non-motor Symptom Questionnaire (NMSQ) was used to screen for the presence of NMS. A mean of 9.73 NMS (SD=4.53) was reported per patient. Forgetfulness, constipation and daytime sleepiness were found to be the most frequent NMS. No differences were found in 9 domains analysis between PD with and without LRRK2 variants. Non-motor symptoms in PD are too important to remain undetected. There are no Clinical characteristics of NMS tend to be similar between LRRK2 variants carriers and non-carriers in Chinese sPD patients.
非运动症状（NMS）在帕金森病（PD）患者中很常见。然而，对于富含亮氨酸重复激酶2（LRRK2）突变的患者的非运动症状了解甚少。本研究旨在阐明中国帕金森病患者中非运动症状之间的关系，并确定帕金森病患者与LRRK2突变患者在非运动症状方面是否存在差异。从山东大学附属省立医院招募了200例散发性帕金森病（sPD）患者。使用非运动症状问卷（NMSQ）筛查非运动症状的存在。每位患者报告的非运动症状平均为9.73种（标准差=4.53）。健忘、便秘和日间嗜睡是最常见的非运动症状。在有和没有LRRK2变异的帕金森病患者的9个领域分析中未发现差异。帕金森病中的非运动症状非常重要，不能不被发现。在中国散发性帕金森病患者中，LRRK2变异携带者和非携带者的非运动症状临床特征往往相似。
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