细胞角蛋白19、甲状腺过氧化物酶、HBME-1和半乳糖凝集素-3在评估甲状腺乳头状癌侵袭性行为中的应用
Cytokeratin 19, thyroperoxidase, HBME-1 and galectin-3 in evaluation of aggressive behavior of papillary thyroid carcinoma.
作者信息
Liu Zeming, Li Xiaoyu, Shi Lan, Maimaiti Yusufu, Chen Tianwen, Li Zhi, Wang Shuntao, Xiong Yiquan, Guo Hui, He Wenshan, Liu Chunping, Nie Xiu, Zeng Wen, Huang Tao
机构信息
Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
Department of Pathology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan, China.
出版信息
Int J Clin Exp Med. 2014 Aug 15;7(8):2304-8. eCollection 2014.
OBJECTIVE
To assess usefulness of cytokeratin 19 (CK19), thyroperoxidase (TPO), Hector Battifora mesothelial epitope-1 (HBME-1) and galectin-3 (GAL3) in evaluation of aggressive behavior of PTCs.
METHODS
All available clinical and pathological data were reviewed in 168 papillary thyroid cancer patients; while the values as predictive markers of PTC were tested by univariate and multivariate analysis.
RESULTS
According to the univariate set of tests, positive expression of CK19 and negative expression of TPO correlated significantly with total tumor diameter (P < 0.05); But there was no association of positive CK19 expression and negative expression of TPO with gender, age, capsular invasion or lymph node metastasis. Moreover, there was no association of positive HBME-1 and galectin-3 expression with clinical aggressive behavior of PTCs.
CONCLUSION
High expression of CK19 and negative expression of TPO indicate total tumor diameter of PTC, but expression of CK19, TPO, HBME-1 and GAL3 has no values in the identification of PTCs with other potentially aggressive behavior.
目的
评估细胞角蛋白19（CK19）、甲状腺过氧化物酶（TPO）、赫克托·巴蒂福拉间皮表位-1（HBME-1）和半乳糖凝集素-3（GAL3）在评估甲状腺乳头状癌（PTC）侵袭性行为中的作用。
方法
回顾了168例甲状腺乳头状癌患者的所有可用临床和病理数据；同时通过单因素和多因素分析测试这些指标作为PTC预测标志物的价值。
结果
根据单因素测试组，CK19的阳性表达和TPO的阴性表达与肿瘤总直径显著相关（P < 0.05）；但CK19阳性表达和TPO阴性表达与性别、年龄、包膜侵犯或淋巴结转移无关。此外，HBME-1和半乳糖凝集素-3的阳性表达与PTC的临床侵袭性行为无关。
结论
CK19的高表达和TPO的阴性表达提示PTC的肿瘤总直径，但CK19、TPO、HBME-1和GAL3的表达在识别具有其他潜在侵袭性行为的PTC方面无价值。
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