通过Wnt2激活Wnt信号通路可促进胰腺癌转移。
Activation of the Wnt pathway through Wnt2 promotes metastasis in pancreatic cancer.
作者信息
Jiang Hua, Li Qingqing, He Chengzhi, Li Fengru, Sheng Haihui, Shen Xiaoying, Zhang Xiaoyan, Zhu Shizhang, Chen Hui, Chen Ximei, Yang Changqing, Gao Hengjun
机构信息
Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120, China.
Department of Gastroenterology, Institute of Digestive Diseases, Tongji Hospital, Tongji University School of Medicine Shanghai 200065, China.
出版信息
Am J Cancer Res. 2014 Sep 6;4(5):537-44. eCollection 2014.
Wnt signaling pathway plays an important role in physiological and pathological process, including in the occurrence and development of tumor. The purpose of this study is to determine whether Wnt2 and sFRP4, key molecules of signaling pathway, are of prognostic value for survival in patients with pancreatic cancer. We performed immunohistochemistry on tissue microarrays containing 90 pancreatic cancer specimens to evaluate the protein expression of Wnt2 and sFRP4. Our results showed that the cytoplasmic expression level of Wnt2 in pancreatic cancer tissues was significantly associated with LNM (P=0.029) and AJCC stage (P=0.008). Additionally, Kaplan-Meier analysis indicated that high Wnt2 expression was significantly correlated with poor clinical outcomes of patients with pancreatic cancer. In conclusion, Wnt2 may play an important role in the development of pancreatic cancer through activation of the Wnt pathways and serve as a potential candidate for treatment target of pancreatic cancer.
Wnt信号通路在生理和病理过程中发挥着重要作用，包括肿瘤的发生和发展。本研究的目的是确定信号通路的关键分子Wnt2和sFRP4对胰腺癌患者的生存是否具有预后价值。我们对包含90个胰腺癌标本的组织芯片进行免疫组化，以评估Wnt2和sFRP4的蛋白表达。我们的结果显示，胰腺癌组织中Wnt2的细胞质表达水平与淋巴结转移（LNM，P=0.029）和美国癌症联合委员会（AJCC）分期（P=0.008）显著相关。此外，Kaplan-Meier分析表明，Wnt2高表达与胰腺癌患者的不良临床结局显著相关。总之，Wnt2可能通过激活Wnt通路在胰腺癌的发展中发挥重要作用，并可作为胰腺癌治疗靶点的潜在候选分子。
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