School of Psychiatry, University of New South Wales, Sydney, NSW, Australia; Clinical Research Unit for Anxiety and Depression (CRUfAD), St. Vincent׳s Hospital, Sydney, NSW, Australia.
School of Psychiatry, University of New South Wales, Sydney, NSW, Australia; Clinical Research Unit for Anxiety and Depression (CRUfAD), St. Vincent׳s Hospital, Sydney, NSW, Australia.
J Affect Disord. 2015 Jan 1;170:78-84. doi: 10.1016/j.jad.2014.08.038. Epub 2014 Sep 1.
Depression is a major risk factor for suicide. Given the strong association between depression and suicide, treatment for depression should be a fundamental component of suicide prevention. Currently it is not. This study aims to demonstrate the usefulness of internet-delivered cognitive behavioural therapy (iCBT) for depression as a means of reducing suicide ideation.
The sample comprised 484 patients who were prescribed iCBT for depression by their primary care physician. The outcomes of interest were major depression, as indexed by the PHQ-8, and suicidal ideation as measured by question 9 of the PHQ-9. Marginal models were used to appropriately analyse available data without biasing parameter estimates.
Following iCBT for depression, suicidal ideation and depression decreased in parallel over time. The prevalence of suicidal ideation reduced from 50% at baseline to 27% after treatment, whilst the prevalence of major depression reduced from 70% to 30%. Depression scores and suicidal ideation decreased after treatment regardless of demographic or clinical variables of interest.
This is a naturalistic study; randomisation and scientific control were not possible.
The current study demonstrates the usefulness of iCBT for depression as a means of reducing suicidal ideation which can be implemented on a large scale without enacting major structural change at the societal level. These findings need to be replicated in randomised controlled trials.
抑郁症是自杀的一个主要风险因素。鉴于抑郁症与自杀之间存在很强的关联,治疗抑郁症应该成为预防自杀的一个基本组成部分。但目前并非如此。本研究旨在证明互联网提供的认知行为疗法(iCBT)在治疗抑郁症方面的有效性,以此作为减少自杀意念的一种手段。
该样本包括 484 名患者,他们的初级保健医生为他们开了 iCBT 治疗抑郁症的处方。主要结果是用 PHQ-8 评估的重度抑郁症,以及 PHQ-9 的第 9 个问题衡量的自杀意念。使用边缘模型可以在不对参数估计产生偏差的情况下适当分析可用数据。
在接受 iCBT 治疗抑郁症后,自杀意念和抑郁程度随时间平行下降。自杀意念的发生率从基线时的 50%降至治疗后的 27%,而重度抑郁症的发生率从 70%降至 30%。治疗后无论感兴趣的人口统计学或临床变量如何,抑郁评分和自杀意念均下降。
这是一项自然主义研究;不可能进行随机化和科学对照。
目前的研究表明,iCBT 治疗抑郁症作为减少自杀意念的一种手段是有效的,可以在不进行重大结构变革的情况下在大规模实施。这些发现需要在随机对照试验中得到复制。