Thévenaz David C, Monnier Christophe A, Balog Sandor, Fiore Gina L
Adolphe Merkle Institute, University of Fribourg , Chemin des Verdiers 4, CH-1700, Fribourg, Switzerland.
Biomacromolecules. 2014 Nov 10;15(11):3994-4001. doi: 10.1021/bm501058n. Epub 2014 Oct 3.
Lanthanide-containing nanoparticles have attracted much attention due to their unique optical properties and potential in nanotechnological applications. An amphiphilic block copolymer of poly(ethylene glycol)-b-poly(ε-caprolactone) methyl ether (mPEG-PCL) was functionalized with a dipicolinic acid (dpa) moiety and coordinated to lanthanide ions to afford Ln(dpa-PCL-PEG-OCH3)33 (Ln = Eu(3+), Tb(3+)). Micelle-like nanoparticles of dpa-PCL-PEG-OCH3 macroligand and metal-centered polymers were prepared by solvent displacement methods. Dynamic light scattering analysis (DLS) and cryogenic transmission electron microscopy images confirmed the presence of solid sphere (<47 nm in diameter) and vesicle (>47 nm in diameter) morphologies. The viability and stability of the lanthanide complexes in micelle-like nanoparticles was explored by DLS and luminescence spectroscopy, and found to be stable for several weeks.
含镧系元素的纳米粒子因其独特的光学性质和在纳米技术应用中的潜力而备受关注。聚（乙二醇）-b-聚（ε-己内酯）甲醚（mPEG-PCL）的两亲性嵌段共聚物用二吡啶甲酸（dpa）部分进行功能化，并与镧系离子配位，得到Ln(dpa-PCL-PEG-OCH3)33（Ln = Eu(3+)，Tb(3+)）。通过溶剂置换法制备了dpa-PCL-PEG-OCH3大环配体和金属中心聚合物的胶束状纳米粒子。动态光散射分析（DLS）和低温透射电子显微镜图像证实存在实心球体（直径<47 nm）和囊泡（直径>47 nm）形态。通过DLS和发光光谱研究了胶束状纳米粒子中镧系配合物的活力和稳定性，发现其在数周内稳定。
