Wassef Hanny, Davignon Jean, Prud'homme Denis, Rabasa-Lhoret Rémi, Faraj May
Institut de Recherches cliniques de Montréal (IRCM), Montréal, Québec, Canada; Department of Nutrition, Faculty of Medicine, Université de Montréal, Montréal, Québec, Canada.
Institut de recherche de l'Hôpital Montfort (IRHM), Ottawa, Ontario, Canada; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, Ontario, Canada.
J Clin Lipidol. 2014 Sep-Oct;8(5):510-9. doi: 10.1016/j.jacl.2014.06.004. Epub 2014 Jun 17.
We previously reported the secretion of apolipoprotein apoC-I, apoC-II, apoC-III, and apoE from adipose tissue in postmenopausal obese women, suggesting their potential regulation by energy balance in humans.
We examined the changes of these apolipoproteins, in relation to changes in cardiometabolic risks, following a hypocaloric diet in overweight/obese women.
METHODS/RESULTS: A total of 137 postmenopausal overweight/obese women who were free of chronic disease were examined at baseline, 56 women of whom were reevaluated following a 6-month hypocaloric diet. At baseline, there was no association between the plasma transferable apolipoproteins with any index of adiposity, insulin sensitivity, lipids, or inflammation, except for apoE with peripheral fat mass (r = 0.18, P < .05), and apoC-II and apoC-III with cholesterol (r = 0.23 and r = 0.20 respectively, P < .05). The hypocaloric diet reduced adiposity, insulin resistance, and inflammatory markers but had no significant effects on plasma transferable apolipoproteins or lipids, whose average concentrations were within normal range at baseline. The changes in total and central, but not peripheral, fat mass associated with changes of apoC-I only (r = 0.28 and r = 0.43; respectively, P < .05). Post-weight-loss apoC-I increased in some women (52%) yet it decreased in others, however there were no differences in cardiometabolic risk factors between the 2 groups.
Plasma apoC-I, apoC-II, apoC-III, and apoE are not associated with adiposity, insulin sensitivity, or inflammation in obese but healthy postmenopausal women. Post-weight-loss changes of total and central fat mass associate with changes of apoC-I.
我们之前报道过绝经后肥胖女性脂肪组织中载脂蛋白apoC-I、apoC-II、apoC-III和apoE的分泌情况，提示它们可能受人体能量平衡的调节。
我们研究了超重/肥胖女性在低热量饮食后，这些载脂蛋白的变化及其与心脏代谢风险变化的关系。
方法/结果：共有137名无慢性病的绝经后超重/肥胖女性在基线时接受了检查，其中56名女性在进行6个月的低热量饮食后再次接受评估。在基线时，血浆中可转移的载脂蛋白与任何肥胖指标、胰岛素敏感性指标、血脂或炎症指标均无关联，但apoE与外周脂肪量有关联（r = 0.18，P < 0.05），apoC-II和apoC-III与胆固醇有关联（分别为r = 0.23和r = 0.20，P < 0.05）。低热量饮食降低了肥胖程度、胰岛素抵抗和炎症标志物，但对血浆可转移载脂蛋白或血脂没有显著影响，其平均浓度在基线时处于正常范围内。仅apoC-I的变化与总体脂肪量和中心脂肪量的变化相关（分别为r = 0.28和r = 0.43；P < 0.05）。体重减轻后，一些女性（52%）的apoC-I升高，而另一些女性则降低，然而两组之间的心脏代谢危险因素并无差异。
在肥胖但健康的绝经后女性中，血浆apoC-I、apoC-II、apoC-III和apoE与肥胖、胰岛素敏感性或炎症无关。体重减轻后总体脂肪量和中心脂肪量的变化与apoC-I的变化相关。
