病毒感染与哮喘：炎症的相互作用？
Viral infections and asthma: an inflammatory interface?
机构信息
School of Medical and Molecular Biosciences, University of Technology Sydney, Sydney, Australia Woolcock Institute of Medical Research, Sydney Medical School, The University of Sydney, Sydney, Australia
Woolcock Institute of Medical Research, Sydney Medical School, The University of Sydney, Sydney, Australia Dept of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, Australia The Children's Hospital at Westmead Clinical School, The University of Sydney, Sydney, Australia.
出版信息
Eur Respir J. 2014 Dec;44(6):1666-81. doi: 10.1183/09031936.00047714. Epub 2014 Sep 18.
Asthma is a chronic inflammatory disease of the airways in which the majority of patients respond to treatment with corticosteroids and β₂-adrenoceptor agonists. Acute exacerbations of asthma substantially contribute to disease morbidity, mortality and healthcare costs, and are not restricted to patients who are not compliant with their treatment regimens. Given that respiratory viral infections are the principal cause of asthma exacerbations, this review article will explore the relationship between viral infections and asthma, and will put forward hypotheses as to why virus-induced exacerbations occur. Potential mechanisms that may explain why current therapeutics do not fully inhibit virus-induced exacerbations, for example, β₂-adrenergic desensitisation and corticosteroid insensitivity, are explored, as well as which aspects of virus-induced inflammation are likely to be attenuated by current therapy.
哮喘是一种气道的慢性炎症性疾病，大多数患者对皮质类固醇和β₂-肾上腺素能受体激动剂的治疗有反应。哮喘的急性加重对疾病发病率、死亡率和医疗保健成本有很大影响，而且不仅限于不遵守治疗方案的患者。鉴于呼吸道病毒感染是哮喘加重的主要原因，本文将探讨病毒感染与哮喘之间的关系，并提出为什么会发生病毒引起的哮喘加重的假说。还探讨了可能的机制，这些机制可以解释为什么目前的治疗方法不能完全抑制病毒引起的哮喘加重，例如β₂-肾上腺素能失敏和皮质激素不敏感，以及当前治疗可能减轻哪些病毒引起的炎症方面。
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