Pereira De Oliveira Rémi, Droillard Clément, Devouassoux Gilles, Rosa-Calatrava Manuel
CIRI, Centre International de Recherche en Infectiologie, Team VirPath, Université de Lyon, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, ENS de Lyon, Lyon, France.
International Research Laboratory RESPIVIR France - Canada, Centre Hospitalier Universitaire de Québec- Université Laval, Québec, QC, Canada.
Front Allergy. 2025 Mar 28;6:1530122. doi: 10.3389/falgy.2025.1530122. eCollection 2025.
Asthma is a heterogenous inflammatory bronchial disease involving complex mechanisms, several inflammatory pathways, and multiples cell-type networks. Bronchial inflammation associated to asthma is consecutive to multiple aggressions on epithelium, such as microbiologic, pollutant, and antigenic agents, which are responsible for both T2 and non-T2 inflammatory responses and further airway remodeling. Because asthma physiopathology involves multiple crosstalk between several cell types from different origins (epithelial, mesenchymal, and immune cells) and numerous cellular effectors, no single and/or representative model is suitable to study the overall of this disease. In this short review, we present and discuss the advantages and limitations of different models to decipher different aspects of virus-related asthma physiopathology and exacerbation.
哮喘是一种异质性炎症性支气管疾病，涉及复杂机制、多种炎症途径和多细胞类型网络。与哮喘相关的支气管炎症是上皮受到多种侵害的结果，如微生物、污染物和抗原性物质，这些会引发2型和非2型炎症反应以及进一步的气道重塑。由于哮喘的病理生理学涉及来自不同来源的多种细胞类型（上皮细胞、间充质细胞和免疫细胞）之间的多次相互作用以及众多细胞效应器，因此没有单一的和/或代表性模型适合研究该疾病的全貌。在这篇简短的综述中，我们展示并讨论了不同模型在解读病毒相关哮喘病理生理学和加重的不同方面的优点和局限性。
